The Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China.
Department of Neurovascular Surgery, First Hospital of Jilin University, Changchun, 130021, China.
Ageing Res Rev. 2024 Jul;98:102324. doi: 10.1016/j.arr.2024.102324. Epub 2024 May 16.
Progressive neuronal dysfunction and death are key features of neurodegenerative diseases; therefore, promoting neurogenesis in neurodegenerative diseases is crucial. With advancements in proteomics and high-throughput sequencing technology, it has been demonstrated that histone post-transcriptional modifications (PTMs) are often altered during neurogenesis when the brain is affected by disease or external stimuli and that the degree of histone modification is closely associated with the development of neurodegenerative diseases. This review aimed to show the regulatory role of histone modifications in neurogenesis and neurodegenerative diseases by discussing the changing patterns and functional significance of histone modifications, including histone methylation, acetylation, ubiquitination, phosphorylation, and lactylation. Finally, we explored the control of neurogenesis and the development of neurodegenerative diseases by artificially modulating histone modifications.
进行性神经元功能障碍和死亡是神经退行性疾病的主要特征；因此，促进神经发生在神经退行性疾病中至关重要。随着蛋白质组学和高通量测序技术的进步，已经证明组蛋白转录后修饰（PTMs）在大脑受到疾病或外部刺激影响时发生神经发生期间经常发生改变，并且组蛋白修饰的程度与神经退行性疾病的发展密切相关。本综述旨在通过讨论组蛋白修饰的变化模式和功能意义，包括组蛋白甲基化、乙酰化、泛素化、磷酸化和乳酰化，展示组蛋白修饰在神经发生和神经退行性疾病中的调节作用。最后，我们探讨了通过人工调节组蛋白修饰来控制神经发生和神经退行性疾病的发展。
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