Andreassen T T, Jørgensen P H
Eur Surg Res. 1985;17(4):264-8. doi: 10.1159/000128477.
Cellulose sponges were cut into two pieces and fibrin sealant was applied to the opposing surfaces, which were held together with sutures. In each rat two sets of sponges, one with and one without fibrin sealant, were implanted subcutaneously for 10 days. The tensile strength and energy absorption of the granulation tissue bridging the incision of the sponges were not influenced by the fibrin sealant. The formation of collagen in fibrin-sealed sponges did not differ from that in ordinary sponges. The results indicated that fibrin sealant does not influence the collagen formation and the mechanical strength after 10 days of healing. At this time the tissue possesses pronounced mechanical strength. The initial strength of sealed sponges possessed considerable mechanical strength (maximum stress 25% and failure energy 12% compared to values achieved after 10 days of implantation). This indicates that the sealant gives mechanical strength in the first days of healing, where the granulation tissue itself only provides minimal strength.
将纤维素海绵切成两片，在相对的表面涂抹纤维蛋白密封剂，并用缝线将它们固定在一起。在每只大鼠皮下植入两组海绵，一组有纤维蛋白密封剂，一组没有，植入10天。连接海绵切口的肉芽组织的拉伸强度和能量吸收不受纤维蛋白密封剂的影响。纤维蛋白密封海绵中胶原蛋白的形成与普通海绵中的没有差异。结果表明，纤维蛋白密封剂在愈合10天后不影响胶原蛋白的形成和机械强度。此时组织具有显著的机械强度。密封海绵的初始强度具有相当大的机械强度（与植入10天后的值相比，最大应力为25%，破坏能量为12%）。这表明密封剂在愈合的最初几天提供机械强度，而此时肉芽组织本身仅提供最小的强度。
