Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA; Research and Development Section, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
Trends Pharmacol Sci. 2024 Jun;45(6):537-551. doi: 10.1016/j.tips.2024.04.007. Epub 2024 May 17.
Cancer cells perturb lipid metabolic pathways for a variety of pro-tumorigenic functions, and deregulated cellular metabolism is a hallmark of cancer cells. Although alterations in lipid metabolism in cancer cells have been appreciated for over 20 years, there are no FDA-approved cancer treatments that target lipid-related pathways. Recent advances pertaining to cancer cell fatty acid synthesis (FAS), desaturation, and uptake, microenvironmental and dietary lipids, and lipid metabolism of tumor-infiltrating immune cells have illuminated promising clinical applications for targeting lipid metabolism. This review highlights emerging pathways and targets for tumor lipid metabolism that may soon impact clinical treatment.
癌细胞扰乱脂质代谢途径以实现多种促肿瘤发生的功能,而细胞代谢失调是癌细胞的一个标志。尽管 20 多年来人们已经认识到癌细胞中脂质代谢的改变,但目前还没有 FDA 批准的针对脂质相关途径的癌症治疗方法。最近在癌症细胞脂肪酸合成(FAS)、去饱和和摄取、微环境和饮食脂质以及肿瘤浸润免疫细胞的脂质代谢方面的进展为靶向脂质代谢提供了有希望的临床应用。本综述强调了肿瘤脂质代谢可能很快会影响临床治疗的新出现的途径和靶点。