Giuliani Stefano, Accetta Celeste, di Martino Simona, De Vitis Claudia, Messina Elena, Pescarmona Edoardo, Fanciulli Maurizio, Ciliberto Gennaro, Mancini Rita, Falcone Italia
SAFU, Department of Research, Advanced Diagnostics and Technological Innovation, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Department of Pathology, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.
Pharmaceuticals (Basel). 2025 Jun 6;18(6):853. doi: 10.3390/ph18060853.
Metabolic reprogramming and epigenetic alterations are fundamental hallmarks of cancer cells, contributing to adaptation, progression, and resistance. In melanoma, high metabolic-epigenetic plasticity enables the rapid modulation of cell states in response to environmental and therapeutic pressures. Recent studies have highlighted a bidirectional crosstalk between cellular metabolism and epigenetic regulation. Epigenetic modifications influence the transcriptional control of metabolic genes, thereby shaping metabolic phenotypes. Conversely, specific metabolites are essential cofactors or substrates for epigenetic enzymes, directly modulating the epigenome. Understanding the intricate mechanisms of this interaction offers opportunities for the development of innovative tumor management that combines epigenetic, metabolic, and therapy interventions. In this review, we summarize the latest evidence on the role of the metabolism-epigenetics axis in melanoma and discuss its potential clinical implications, aiming to provide a comprehensive overview of metabolic/epigenetic interconnections.
代谢重编程和表观遗传改变是癌细胞的基本特征，有助于癌细胞适应、进展和产生耐药性。在黑色素瘤中，高度的代谢-表观遗传可塑性使细胞状态能够快速响应环境和治疗压力而发生调节。最近的研究强调了细胞代谢与表观遗传调控之间的双向相互作用。表观遗传修饰影响代谢基因的转录控制，从而塑造代谢表型。相反，特定的代谢物是表观遗传酶的必需辅助因子或底物，直接调节表观基因组。了解这种相互作用的复杂机制为开发结合表观遗传、代谢和治疗干预措施的创新肿瘤管理方法提供了机会。在本综述中，我们总结了代谢-表观遗传学轴在黑色素瘤中作用的最新证据，并讨论其潜在的临床意义，旨在全面概述代谢/表观遗传的相互联系。
