Department of Neurology and Clinical Neuroscience, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nat Commun. 2024 May 18;15(1):4256. doi: 10.1038/s41467-024-48651-0.
After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition, marked by neurologic symptoms such as cognitive deficits, olfactory dysfunction, and fatigue. Despite this, biomarkers and pathophysiological understandings of this condition remain limited. Employing magnetic resonance imaging, we conduct a comparative analysis of cerebral microstructure among patients with Post-COVID-Condition, healthy controls, and individuals that contracted COVID-19 without long-term symptoms. We reveal widespread alterations in cerebral microstructure, attributed to a shift in volume from neuronal compartments to free fluid, associated with the severity of the initial infection. Correlating these alterations with cognition, olfaction, and fatigue unveils distinct affected networks, which are in close anatomical-functional relationship with the respective symptoms.
感染 COVID-19 后，大量患者会出现新冠后症状，表现为认知障碍、嗅觉功能障碍和疲劳等神经系统症状。尽管如此，该病症的生物标志物和病理生理学机制仍了解有限。本研究采用磁共振成像技术，对新冠后症状患者、健康对照者和无长期症状的 COVID-19 感染患者的脑微观结构进行了对比分析。研究发现，脑微观结构广泛改变，与初始感染严重程度相关，表现为神经元区室到自由液体的体积转移。将这些改变与认知、嗅觉和疲劳相关联，揭示了不同的受影响网络，这些网络与各自的症状在解剖和功能上密切相关。
Zotero 插件
