T细胞在预防啮齿动物疟疾传播中的作用。
Role of T cells in preventing transmission of rodent malaria.
作者信息
Harte P G, Rogers N C, Targett G A
出版信息
Immunology. 1985 Sep;56(1):1-7.
Abstract
Transmission blocking immunity induced by microgamete vaccination is fully effective for at least 12 months. Passive transfer of immune T cells reduced transmission of a subsequent infection by 95%, the effect being partly due to a significant reduction in numbers of circulating gametocytes during the infection. This immunity was apparently independent of specific antibody, though these were produced within a few days after challenge infection and was mediated by a T cell of the GK1.5+, Ly 2.2 phenotype. Immune serum and immune T cells, administered together, showed a strong additive effect and blocked transmission completely.
摘要
微小配子疫苗诱导的传播阻断免疫至少12个月内完全有效。免疫T细胞的被动转移使后续感染的传播减少了95%，这种效果部分归因于感染期间循环配子体数量的显著减少。这种免疫显然独立于特异性抗体，尽管在攻击感染后几天内会产生特异性抗体，并且由GK1.5+、Ly 2.2表型的T细胞介导。免疫血清和免疫T细胞一起施用显示出强烈的相加效应并完全阻断传播。
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