用纯化的血液期疟疾抗原对小鼠进行疫苗接种：保护作用与T细胞介导免疫的相关性。
Vaccination with a purified blood-stage malaria antigen in mice: correlation of protection with T cell mediated immunity.
作者信息
Playfair J H, De Souza J B, Freeman R R, Holder A A
出版信息
Clin Exp Immunol. 1985 Oct;62(1):19-23.
Abstract
A purified 230,000 mol wt protein antigen from the lethal mouse malaria parasite Plasmodium yoelii YM which had previously been shown to be highly effective as a vaccine, was tested for its ability to stimulate specific helper T cells and T cells responsible for delayed hypersensitivity. Strong stimulation was found in both assays, but larger doses were required for delayed hypersensitivity, correlating well with the requirements for protection. It is suggested that T stimulation may be a requirement for effective protection by purified antigens in malaria.
摘要
从致死性小鼠疟原虫约氏疟原虫YM中纯化出的一种分子量为230,000的蛋白质抗原，此前已证明其作为疫苗具有高效性，现对其刺激特异性辅助性T细胞和引发迟发型超敏反应的T细胞的能力进行测试。在两种检测中均发现有强烈刺激，但引发迟发型超敏反应需要更大剂量，这与保护所需条件密切相关。提示T细胞刺激可能是疟疾中纯化抗原实现有效保护的必要条件。
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