Guo Shiyun, Ding Ruidong, Zhao Qian, Wang Xu, Lv Shuangyu, Ji Xin-Ying
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, Henan, China.
Kaifeng Key Laboratory for Infectious Diseases and Biosafety, Kaifeng, 475004, Henan, China.
Mol Biotechnol. 2025 May;67(5):1800-1813. doi: 10.1007/s12033-024-01188-5. Epub 2024 May 19.
PEST-containing nuclear protein (PCNP), a short-lived small nuclear protein with 178 amino acids, is a nuclear protein containing two PEST sequences. PCNP is highly expressed in several malignant tumors such as cervical cancer, rectal cancer, and lung cancer. It is also associated with cell cycle regulation and the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and Wnt signaling pathways during tumor growth. The present article discuss how PCNP regulates the PI3K/AKT/mTOR and Wnt signaling pathways and related proteins, and the ubiquitination of PCNP regulates tumor cell cycle as well as the progress of the application of PCNP in the pathophysiology and treatment of colon cancer, human ovarian cancer, thyroid cancer, lung adenocarcinoma and oral squamous cell carcinoma. The main relevant articles were retrieved from PubMed, with keywords such as PEST-containing nuclear protein (PCNP), cancer (tumor), and signaling pathways as inclusion/exclusion criteria. Relevant references has been included and cited in the manuscript.
含PEST核蛋白（PCNP）是一种由178个氨基酸组成的短寿命小核蛋白，是一种含有两个PEST序列的核蛋白。PCNP在宫颈癌、直肠癌和肺癌等多种恶性肿瘤中高表达。在肿瘤生长过程中，它还与细胞周期调控以及磷酸肌醇3激酶/蛋白激酶B/雷帕霉素哺乳动物靶点（PI3K/AKT/mTOR）和Wnt信号通路有关。本文讨论了PCNP如何调节PI3K/AKT/mTOR和Wnt信号通路及相关蛋白，以及PCNP的泛素化如何调节肿瘤细胞周期，以及PCNP在结肠癌、人卵巢癌、甲状腺癌、肺腺癌和口腔鳞状细胞癌的病理生理和治疗中的应用进展。主要相关文章从PubMed检索，以含PEST核蛋白（PCNP）、癌症（肿瘤）和信号通路等关键词作为纳入/排除标准。相关参考文献已纳入并在稿件中引用。
