Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Department of Biostatistics and Computing, Yonsei University, Seoul 03722, Korea.
Dig Liver Dis. 2024 Nov;56(11):1880-1886. doi: 10.1016/j.dld.2024.05.003. Epub 2024 May 18.
BACKGROUNDS & AIMS: Menopause, characterized by a sudden decline in estrogen levels, has significant effects on women's health, especially when it occurs early. This study aimed to investigate the associations between menopausal age and incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) using a large cohort and a long-term follow-up.
Menopausal age was categorized into four groups (G1-4 [<40, 40-44, 45-49, and ≥50 years, respectively]). Cox proportional hazards regression analysis was used to assess the risk of developing MAFLD during the follow-up period according to the menopausal age categories.
A total of 1,888 participants were included in the final analysis and followed for a median period of 12.3 years. The unadjusted hazard ratios (95 % CIs) for the incidence of new-onset MAFLD were 1.11 (0.93-1.32), 1.15 (0.90-1.47), and 1.52 (1.12-2.07) in G3, G2, and G1, respectively, compared with that in G4. After adjusting for confounders, the hazard ratio (95 % CIs) for the incidence of new-onset MAFLD was 1.40 (1.00-1.95) in G1 compared with that in G4.
The risk of developing MAFLD was higher in women with premature menopause (<40 years) than in those with menopause aged ≥50 years.
绝经是指雌激素水平突然下降，对女性健康有重大影响，尤其是绝经发生较早时。本研究旨在使用大型队列和长期随访来探讨绝经年龄与代谢相关脂肪性肝病（MAFLD）发病之间的关系。
绝经年龄分为四组（G1-4 [<40、40-44、45-49 和≥50 岁]）。使用 Cox 比例风险回归分析根据绝经年龄组评估随访期间发生 MAFLD 的风险。
共有 1888 名参与者被纳入最终分析，并随访了中位数为 12.3 年的时间。未调整的新发病例 MAFLD 的风险比（95%CI）在 G3、G2 和 G1 组分别为 1.11（0.93-1.32）、1.15（0.90-1.47）和 1.52（1.12-2.07），与 G4 组相比。调整混杂因素后，G1 组新发 MAFLD 的风险比（95%CI）为 1.40（1.00-1.95），与 G4 组相比。
与绝经年龄≥50 岁的女性相比，绝经年龄过早（<40 岁）的女性发生 MAFLD 的风险更高。
