Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China.
Yi Chuan. 2023 Dec 20;45(12):1100-1113. doi: 10.16288/j.yczz.23-188.
Mycobacterium infection can affect the host's immune function by secreting extracellular effector proteins. ESX (or type VII) system plays an important role in the secretion of effector proteins. ESX system is the protein export system in mycobacteria and many actinomycetes. However, how ESX system secretes and underlying mechanism of action remain unclear. In this review, we introduce the components, function, classification of ESX system and the process of substrates transfer to the peripheral space via this system, and discuss the roles of ESX system in antibiotics resistance, persistence, host-phage interaction, new drug targets. We hope to provide insights into the discovery of new drugs and vaccine antigens for tuberculosis.
分枝杆菌感染可以通过分泌细胞外效应蛋白来影响宿主的免疫功能。ESX（或 VII 型）系统在效应蛋白的分泌中起着重要作用。ESX 系统是分枝杆菌和许多放线菌中的蛋白质输出系统。然而，ESX 系统如何分泌以及作用机制仍不清楚。在这篇综述中，我们介绍了 ESX 系统的组成、功能、分类以及通过该系统将底物转移到外周空间的过程，并讨论了 ESX 系统在抗生素耐药性、持久性、宿主-噬菌体相互作用、新药靶方面的作用。我们希望为结核病新药和疫苗抗原的发现提供思路。
