Lee Da Young, Park Jinmo, Han Dahee, Choi Yeongwoo, Kim Jin Soo, Mariano Ermie, Lee Juhyun, Yun Seung Hyeon, Lee Seung Yun, Park Sungkwon, Bhang Suk Ho, Hur Sun Jin
Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea.
Division of Animal Science, Institute of Agriculture & Life Science, Gyeongsang National University, Jinju, Republic of Korea.
Crit Rev Food Sci Nutr. 2025;65(13):2506-2537. doi: 10.1080/10408398.2024.2345817. Epub 2024 May 19.
Cultured meat is expected to become an important material for future food production; however, contrary to initial expectations, the full-scale industrialization of cultured meat is slow and the actual level and opened technology amount is very limited. This study reviews the publicly available technologies of cultured meat and suggests future developmental directions and research agenda. As a result of analyzing papers, patents, and press releases published over the past 10 years, it was found that cultured meat production technology is still at the prototype production level. This is because most papers published are about culture medium and scaffold development, culture conditions, and there is almost no research on finished cultured meat products. Worldwide, most of the filed patents are for producing cultured meat principles; most of them do not use food-grade materials and are not economically feasible for industrialization. Therefore, future research on the industrialization of cultured meat should focus on effective acquisition technologies for satellite cells; cell lineage and undifferentiated state maintenance technologies; the development of serum-free media and culture devices; the prevention of genetic modification, safety verification, and mass production. Furthermore, basic research on mechanisms and influencing factors related to cultured meat production is warranted.
cultured meat is expected to become an important material for future food production; however, contrary to initial expectations, the full-scale industrialization of cultured meat is slow and the actual level and opened technology amount is very limited. This study reviews the publicly available technologies of cultured meat and suggests future developmental directions and research agenda. As a result of analyzing papers, patents, and press releases published over the past 10 years, it was found that cultured meat production technology is still at the prototype production level. This is because most papers published are about culture medium and scaffold development, culture conditions, and there is almost no research on finished cultured meat products. Worldwide, most of the filed patents are for producing cultured meat principles; most of them do not use food-grade materials and are not economically feasible for industrialization. Therefore, future research on the industrialization of cultured meat should focus on effective acquisition technologies for satellite cells; cell lineage and undifferentiated state maintenance technologies; the development of serum-free media and culture devices; the prevention of genetic modification, safety verification, and mass production. Furthermore, basic research on mechanisms and influencing factors related to cultured meat production is warranted.
培养肉有望成为未来食品生产的重要原料;然而,与最初的预期相反,培养肉的全面工业化进程缓慢,实际水平和公开的技术数量非常有限。本研究回顾了培养肉的公开可用技术,并提出了未来的发展方向和研究议程。通过分析过去10年发表的论文、专利和新闻稿发现,培养肉生产技术仍处于原型生产水平。这是因为大多数发表的论文都是关于培养基和支架开发、培养条件的,几乎没有关于成品培养肉产品的研究。在全球范围内,大多数已提交的专利都是关于培养肉生产原理的;其中大多数不使用食品级材料,在经济上也不适合工业化。因此,未来培养肉工业化的研究应集中在卫星细胞的有效获取技术;细胞谱系和未分化状态维持技术;无血清培养基和培养装置的开发;防止基因改造、安全验证和大规模生产。此外,有必要对培养肉生产相关的机制和影响因素进行基础研究。