Zhao Zhihao, Qi Diya, Zhang Zeqing, Du Xin, Zhang Fengyun, Ma Ruicong, Liang Yi, Zhao Yuewu, Gao Ying, Yang Yu
Department of Cardiology, the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Xuzhou, People's Republic of China.
Department of Cardiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, People's Republic of China.
J Inflamm Res. 2024 May 14;17:3003-3012. doi: 10.2147/JIR.S459989. eCollection 2024.
The aim of this study was to explore the relationship between inflammatory cytokines and the risk of heart failure (HF) readmission in patients with heart failure with preserved ejection fraction (HFpEF).
We enrolled 429 patients with HFpEF admitted to the cardiology department in our hospital from January 2020 to July 2022. The patients were divided into the readmission or non-readmission groups according to whether they were readmitted for heart failure within 1 year of discharge. The clinical features and laboratory date of the subjects were collected and analyzed. Multivariate cox regression analysis was used to identify predictors of HF readmission. In addition, receiver operating characteristic (ROC) curves were used to determine the prognostic value of each factor.
The levels of IL-1β, IL-6, IL-10, IL-17, TNF-α, NT-proBNP, heart rate, total cholesterol and NYHA class were significantly higher in the readmission group than in the non-readmission group ( < 0.05). IL-1β, IL-6, IL-17, TNF-α, NT-proBNP, heart rate and NYHA class were identified as independent predictors of HF readmission.
Inflammatory markers, including IL-1β, IL-6, IL-17 and TNF-α were related to the HF readmission in patients with HFpEF.
本研究旨在探讨炎症细胞因子与射血分数保留的心力衰竭（HFpEF）患者心力衰竭再入院风险之间的关系。
我们纳入了2020年1月至2022年7月期间在我院心内科住院的429例HFpEF患者。根据患者出院后1年内是否因心力衰竭再次入院，将其分为再入院组和非再入院组。收集并分析了受试者的临床特征和实验室数据。采用多因素cox回归分析确定HF再入院的预测因素。此外，使用受试者工作特征（ROC）曲线来确定各因素的预后价值。
再入院组的IL-1β、IL-6、IL-10、IL-17、TNF-α、NT-proBNP、心率、总胆固醇和NYHA分级水平显著高于非再入院组（<0.05）。IL-1β、IL-6、IL-17、TNF-α、NT-proBNP、心率和NYHA分级被确定为HF再入院的独立预测因素。
包括IL-1β、IL-6、IL-17和TNF-α在内的炎症标志物与HFpEF患者的HF再入院有关。
