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老年患者与非老年患者接受永久性起搏器植入的手术及心血管结局——一项全国性队列分析

Procedural and cardiovascular outcomes of geriatric vs non-geriatric patients undergoing permanent pacemaker implantation - a nationwide cohort analysis.

作者信息

Shaik Ayesha, Rojulpote Madhuwani, Roma Nicholas, Patel Neel, Sattar Yasar, Thyagaturu Harshith, Chobufo Muchi Ditah, Bansal Raahat, Alharbi Anas, Taha Amro, Raina Sameer, Gonuguntla Karthik

机构信息

Department of Cardiovascular Medicine, Hartford Hospital Hartford, CT, USA.

Department of Internal Medicine, Rush University Chicago, IL, USA.

出版信息

Am J Cardiovasc Dis. 2024 Apr 15;14(2):128-135. doi: 10.62347/FIRV6475. eCollection 2024.

Abstract

BACKGROUND

Permanent pacemaker implantation is increasing exponentially to treat atrio-ventricular block and symptomatic bradyarrhythmia. Despite being a minor surgery, immediate complications such as pocket infection, pocket hematoma, pneumothorax, hemopericardium, and lead displacement do occur.

METHODS

The Nationwide Inpatient Sample was queried from 2016 to 2018 to identify patients with pacemakers using ICD-10 procedure code. The Chi-square test was used for statistical analysis.

RESULTS

The sample size consisted of 443,460 patients with a pacemaker, 26% were <70 years (male 57%, mean age of (60.6±9.7) yr, Caucasian 70%) and 74% were ≥70 years (male 50%, mean age of (81.4±5.9) yr, Caucasian 79%). Upon comparison of rates in the young vs elderly: mortality (1.6% vs 1.5%; P<0.01), obesity (26% vs 13%; P<0.001), coronary artery disease (40% vs 49%; P<0.001), HTN (74% vs 87%; P<0.01), anemia (4% vs 5%; P<0.01), atrial fibrillation (34% vs 49%; P<0.01), peripheral artery disease (1.7% vs 3%; P<0.01), CHF (31% vs 39%; P<0.001), diabetes (31% vs 27.4%; P<0.01), vascular complications (1.1% vs 1.2%; P<0.01), pocket hematoma (0.5% vs 0.8%; P<0.01), AKI (16% vs 21%; P<0.01), hemopericardium (0.1% vs 0.1%; P = 0.1), hemothorax (0.3% vs 0.2%; P<0.01), cardiac tamponade (0.4% vs 0.5%; P<0.01), pericardiocentesis (0.4% vs 0.4%; P<0.01), cardiogenic shock (4% vs 2.3%; P<0.01), respiratory complications (1.9% vs 0.9%; P<0.01), mechanical ventilation (5.1% vs 2.9%; P<0.01); post-op bleed (0.5% vs 0.3%; P<0.01), need for transfusion (4.8% vs 3.8%; P<0.01), severe sepsis (0.6% vs 0.5%; P<0.01 ), septic shock (2% vs 1%; P<0.01), bacteraemia (0.8% vs 0.4%; P<0.01), lead dislodgement (1.4% vs 1.1%; P<0.01).

CONCLUSIONS

Our study revealed that the overall complication rates were lower in the elderly despite higher co-morbidities. This aligns with previous studies which showed lower rates in the elderly. Hence providers should not hesitate to provide guideline driven pacemaker placement in the elderly especially in patients with good life expectancy.

摘要

背景

永久性起搏器植入术的数量正在呈指数级增长,用于治疗房室传导阻滞和有症状的缓慢性心律失常。尽管这是一个小手术,但仍会出现一些即刻并发症,如囊袋感染、囊袋血肿、气胸、心包积血和导线移位。

方法

查询2016年至2018年的全国住院患者样本,使用ICD-10手术编码识别植入起搏器的患者。采用卡方检验进行统计分析。

结果

样本包括443460例植入起搏器的患者,其中26%年龄小于70岁(男性占57%,平均年龄为(60.6±9.7)岁,白种人占70%),74%年龄大于等于70岁(男性占50%,平均年龄为(81.4±5.9)岁,白种人占79%)。比较年轻人和老年人的发生率:死亡率(1.6%对1.5%;P<0.01)、肥胖(26%对13%;P<0.001)、冠状动脉疾病(40%对49%;P<0.001)、高血压(74%对87%;P<0.01)、贫血(4%对5%;P<0.01)、心房颤动(34%对49%;P<0.01)、外周动脉疾病(1.7%对3%;P<0.01)、心力衰竭(31%对39%;P<0.001)、糖尿病(31%对27.4%;P<0.01)、血管并发症(1.1%对1.2%;P<0.01)、囊袋血肿(0.5%对0.8%;P<0.01)、急性肾损伤(16%对21%;P<0.01)、心包积血(0.1%对0.1%;P = 0.1)、血胸(0.3%对0.2%;P<0.01)、心脏压塞(0.4%对0.5%;P<0.01)、心包穿刺(0.4%对0.4%;P<0.01)、心源性休克(4%对2.3%;P<0.01)、呼吸并发症(1.9%对0.9%;P<0.01)、机械通气(5.1%对2.9%;P<0.01);术后出血(0.5%对0.3%;P<0.01)、输血需求(4.8%对3.8%;P<0.01)、严重脓毒症(0.6%对0.5%;P<0.01)、感染性休克(2%对1%;P<0.01)、菌血症(0.8%对0.4%;P<0.01)、导线移位(1.4%对1.1%;P<0.01)。

结论

我们的研究表明,尽管老年人合并症较多,但其总体并发症发生率较低。这与之前显示老年人发生率较低的研究结果一致。因此,医疗服务提供者应毫不犹豫地为老年人,尤其是预期寿命较长的患者,提供符合指南的起搏器植入治疗。

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