Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.
Departments of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
Medicine (Baltimore). 2023 Mar 3;102(9):e33031. doi: 10.1097/MD.0000000000033031.
Extraintestinal manifestations (EIMs) are common in patients with inflammatory bowel disease (IBD); however, studies surrounding EIMs are lacking, particularly in Asia. This study aimed to identify risk factors by analyzing the characteristics of patients with EIMs. From January 2010 to December 2020, the medical records of 531 patients diagnosed with IBD (133 with Crohn disease [CD] and 398 with ulcerative colitis [UC]) were reviewed. The patients' baseline characteristics and risk factors were analyzed by dividing them into 2 groups according to EIMs presence. The prevalence of EIMs in all patients with IBD was 12.4% (n = 66), of which CD and UC prevalences were 19.5% (n = 26) and 10.1% (n = 40), respectively. The articular (7.9%, n = 42), cutaneous (3.6%, n = 19), ocular (1.5%, n = 8), and hepatobiliary types (0.8%, n = 4) of EIMs were observed. Two or more EIMs occurred in only 1.2% of all IBD patients (n = 6). Multivariate analysis revealed that the risk factors for the occurrence of EIMs were a follow-up period ≥ 10 years (odds ratio, 2.106; 95% confidence interval, 1.187-3.973; P = .021) and treatment with biologics (odds ratio, 1.963; 95% confidence interval, 1.070-3.272; P = .037). The EIMs prevalence in patients with IBD was 12.4%, and the particular type was the most common, with EIMs occurring more frequently in patients with CD than in those with UC. Patients who have been treated for IBD for more than 10 years or who are using biologics should be carefully monitored as they are at high risk for EIMs.
肠外表现（EIMs）在炎症性肠病（IBD）患者中很常见；然而，针对 EIMs 的研究很少，特别是在亚洲。本研究旨在通过分析 EIMs 患者的特征来确定危险因素。
2010 年 1 月至 2020 年 12 月，回顾了 531 例诊断为 IBD（133 例克罗恩病[CD]和 398 例溃疡性结肠炎[UC]）患者的病历。根据 EIMs 的存在，将患者的基线特征和危险因素分为 2 组进行分析。所有 IBD 患者中 EIMs 的患病率为 12.4%（n=66），其中 CD 和 UC 的患病率分别为 19.5%（n=26）和 10.1%（n=40）。观察到关节（7.9%，n=42）、皮肤（3.6%，n=19）、眼（1.5%，n=8）和肝胆类型（0.8%，n=4）的 EIMs。只有 1.2%的所有 IBD 患者（n=6）出现 2 种或以上的 EIMs。多变量分析显示，发生 EIMs 的危险因素为随访时间≥10 年（比值比，2.106；95%置信区间，1.187-3.973；P=0.021）和生物制剂治疗（比值比，1.963；95%置信区间，1.070-3.272；P=0.037）。
IBD 患者的 EIMs 患病率为 12.4%，其中特定类型最常见，CD 患者的 EIMs 发生率高于 UC 患者。对于接受 IBD 治疗超过 10 年或正在使用生物制剂的患者，应密切监测其 EIMs 风险较高。
