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对健康越南人群免疫系统的全面分析。

A comprehensive analysis of the immune system in healthy Vietnamese people.

作者信息

Huynh Dinh Chien, Nguyen Minh Phuong, Ngo Dinh Trung, Nguyen Xuan Hung, Nguyen Dac Tu, Mai Thi Hien, Le Thi Huyen, Hoang Mai Duy, Le Khac Linh, Nguyen Khoi Quan, Nguyen Viet Hoang, Kelley Keith W

机构信息

VinUniversity, Hanoi, Viet Nam.

Military Central Hospital 108, Hanoi, Viet Nam.

出版信息

Heliyon. 2024 May 5;10(9):e30647. doi: 10.1016/j.heliyon.2024.e30647. eCollection 2024 May 15.

DOI:10.1016/j.heliyon.2024.e30647
PMID:38765090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11101793/
Abstract

Lifestyle, diet, socioeconomic status and genetics all contribute to heterogeneity in immune responses. Vietnam is plagued with a variety of health problems, but there are no available data on immune system values in the Vietnamese population. This study aimed to establish reference intervals for immune cell parameters specific to the healthy Vietnamese population by utilizing multi-color flow cytometry (MCFC). We provide a comprehensive analysis of total leukocyte count, quantitative and qualitative shifts within lymphocyte subsets, serum and cytokine and chemokine levels and functional attributes of key immune cells including B cells, T cells, natural killer (NK) cells and their respective subpopulations. By establishing these reference values for the Vietnamese population, these data contribute significantly to our understanding of the human immune system variations across diverse populations. These data will be of substantial comparative value and be instrumental in developing personalized medical approaches and optimizing diagnostic strategies for individuals based on their unique immune profiles.

摘要

生活方式、饮食、社会经济地位和基因都导致免疫反应的异质性。越南饱受各种健康问题困扰，但尚无越南人群免疫系统数值的可用数据。本研究旨在通过利用多色流式细胞术（MCFC）为健康越南人群建立特定免疫细胞参数的参考区间。我们对总白细胞计数、淋巴细胞亚群内的定量和定性变化、血清以及细胞因子和趋化因子水平以及包括B细胞、T细胞、自然杀伤（NK）细胞及其各自亚群在内的关键免疫细胞的功能属性进行了全面分析。通过为越南人群建立这些参考值，这些数据对我们理解不同人群的人类免疫系统差异有显著贡献。这些数据将具有重要的比较价值，并有助于基于个体独特的免疫谱制定个性化医疗方法和优化诊断策略。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1198/11101793/d9feddbf205b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1198/11101793/55a22dd564a6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1198/11101793/ce4339c0f746/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1198/11101793/68ae572c4f8e/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1198/11101793/36d6937c6265/fx2.jpg
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