Önen Özlem, Özek Erkuran Handan, Bağ Özlem, Abacıgil Filiz
Child and Adolescent Psychiatry Unit, SBU Izmir Dr. Behcet Uz Children's Research and Training Hospital, Izmir, Turkey.
Department of Social Pediatrics Unit, SBU Izmir Dr. Behcet Uz Children's Research and Training Hospital, Izmir, Turkey.
Psychiatry Clin Psychopharmacol. 2021 Dec 1;31(4):425-433. doi: 10.5152/pcp.2021.21137. eCollection 2021 Dec.
There is increasing evidence that immunological and inflammatory dysfunctions play an essential role in the initiation and progression of major psychiatric disorders. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume can be used as markers of systemic inflammation in different diseases. We aimed to investigate these blood count parameters in children and adolescents diagnosed with major depressive disorder.
Designed as a case-control study, our sample consisted of patients aged 9-16 years referred to Child and Adolescent Psychiatry and pediatrics outpatient clinics for the first time and diagnosed with major depressive disorder according to diagnostic criteria, and healthy children and adolescents matched at a ratio of 1 to 2. Data of 58 cases and 90 healthy controls evaluated between 01.07.2019 and 01.07.2020 were included.
Platelet-to-lymphocyte ratio values were significantly higher in the case group. No significant difference was found between patient and control groups regarding other blood count parameters. When depression group was compared in terms of all parameters as those who committed suicide and those did not, significant difference was found between the 3 groups in terms of platelet-to-lymphocyte ratio values. The intergroup difference in platelet-to-lymphocyte ratio was found between the depression group without suicide and the control group. No significant relationship was found between other parameters and Children's Depression Inventory Scale scores. We determined a cut-off value of 112.5 for platelet-to-lymphocyte ratio (with sensitivity of 70% and specificity of 63%).
Platelet-to-lymphocyte ratio might be an important parameter in the clinical follow-up of major depressive disorder.
越来越多的证据表明，免疫和炎症功能障碍在主要精神疾病的发生和发展中起着至关重要的作用。中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及平均血小板体积可作为不同疾病全身炎症的标志物。我们旨在研究被诊断为重度抑郁症的儿童和青少年的这些血细胞计数参数。
本研究设计为病例对照研究，样本包括首次转诊至儿童和青少年精神病学及儿科门诊、根据诊断标准被诊断为重度抑郁症的9至16岁患者，以及按1比2比例匹配的健康儿童和青少年。纳入了2019年7月1日至2020年7月1日期间评估的58例病例和90例健康对照的数据。
病例组的血小板与淋巴细胞比值显著更高。在其他血细胞计数参数方面，患者组和对照组之间未发现显著差异。当按是否自杀将抑郁症组的所有参数进行比较时，三组在血小板与淋巴细胞比值方面存在显著差异。血小板与淋巴细胞比值的组间差异存在于无自杀行为的抑郁症组和对照组之间。其他参数与儿童抑郁量表得分之间未发现显著关系。我们确定血小板与淋巴细胞比值的临界值为112.5（敏感性为70%，特异性为63%）。
血小板与淋巴细胞比值可能是重度抑郁症临床随访中的一个重要参数。
