Department of Child and Adolescent Psychiatry, Katip Çelebi University School of Medicine, İzmir, Turkey.
Department of Child and Adolescent Psychiatry, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, Turkey.
Psychiatry Res. 2018 Oct;268:426-431. doi: 10.1016/j.psychres.2018.08.007. Epub 2018 Aug 6.
We aimed to investigate the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with major depression. Sixty-seven adolescents and 121 healthy controls were enrolled in the study. The diagnosis was made by using both the Kiddie and Young Adult Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version and the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition. The severity of depressive symptoms was evaluated using the Beck depression inventory (BDI). The neutrophil-lymphocyte ratios of the adolescents with depression were significantly higher than those of the control group, even after adjusting for age, sex, BMI, and BDI scores, whereas there was no significant difference in platelet-lymphocyte ratios. A positive correlation between the severity of depression and neutrophil-lymphocyte ratios and platelet-lymphocyte ratios were determined in the case group. The results of this study may promote the hypothesis that inflammation plays an important role in the etiology of major depression in adolescents.
我们旨在研究青少年重度抑郁症患者的中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值。本研究共纳入 67 名青少年患者和 121 名健康对照者。使用儿童和青少年情感障碍和精神分裂症现患和终身版本定式检查（Kiddie and Young Adult Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version）和精神障碍诊断与统计手册第五版（Diagnostic and Statistical Manual of Mental Disorders Fifth Edition）的诊断标准进行诊断。采用贝克抑郁自评量表（Beck depression inventory，BDI）评估抑郁症状严重程度。即使在调整了年龄、性别、BMI 和 BDI 评分后，与对照组相比，抑郁症青少年的中性粒细胞与淋巴细胞比值仍显著升高，而血小板与淋巴细胞比值则无显著差异。在病例组中，还确定了抑郁严重程度与中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值之间存在正相关关系。本研究结果可能支持炎症在青少年重度抑郁症发病机制中起重要作用的假说。
