Scorzo Augustino V, Byrd Brook K, Strawbridge Rendall R, Davis Scott C
Dartmouth College, Thayer School of Engineering, 15 Thayer Drive, Hanover, NH, USA 03755.
Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12361. doi: 10.1117/12.2650599. Epub 2023 Mar 14.
Neurosurgical fluorescence guidance relies on contrast agents to identify tumor regions to aid in increasing the extent of resection. Existing contrast agents for this indication each have their own limitation: unpredictable contrast from tumor heterogeneity, significant extravasation into the background brain and long incubation times. An ideal contrast agent should have high and rapid contrast that persists well into the surgical procedure. By using a whole animal hyperspectral cryo-imaging system several CAs were screened for these favorable properties and compared to the gold standard of gadolinium enhanced MR. Herein, we briefly report on the leading candidate Rd-PEG1k, which shows high contrast within minutes of administration that persists for at least 90 minutes.
神经外科荧光引导依赖于造影剂来识别肿瘤区域，以帮助扩大切除范围。现有的用于该适应症的造影剂都有各自的局限性：肿瘤异质性导致的不可预测的对比度、大量渗漏到周围脑组织以及较长的孵育时间。理想的造影剂应具有高对比度且快速显影，并在整个手术过程中持续良好。通过使用全动物高光谱低温成像系统，筛选了几种具有这些优良特性的造影剂，并与钆增强磁共振成像的金标准进行了比较。在此，我们简要报告主要候选物Rd-PEG1k，它在给药后几分钟内就显示出高对比度，并且至少持续90分钟。
