Kvaløy S, Langholm R, Kaalhus O, Marton P F, Høst H, Godal T
Scand J Haematol. 1985 Aug;35(2):137-44. doi: 10.1111/j.1600-0609.1985.tb01562.x.
Cell surface marker profiles were studied on cell suspensions from monoclonal B cell lymphomas. Surface immunoglobulin (sIg) was examined in 178 cases, whereas combined data with sIg and receptors for complement (C3) were available in 99/178 cases. The results showed that B cell lymphomas can be divided into distinct immunological subsets according to surface marker expression. Whereas some histologic subgroups (diffuse centroblastic/centrocytic, centrocytic, immunocytoma) (Kiel classification) consisted of few immunological subtypes, others were more heterogeneous (follicular centroblastic/centrocytic, centroblastic, lymphocytic). By combining immunological and histological subgroups, more than 40 phenotypes could be identified; this diversity most likely reflects, the heterogeneity of the B cell compartment. As part of the same study the prognostic significance of cell marker phenotypes was examined. Survival analysis undertaken on 149/178 patients did not uncover any significant relationship between type of heavy or light chain expression, C3 receptor expression and clinical outcome. Our data do not confirm recent findings that the type of immunological phenotype may be of prognostic significance.
对单克隆B细胞淋巴瘤的细胞悬液进行了细胞表面标志物分析。检测了178例患者的表面免疫球蛋白（sIg），其中99/178例患者同时有sIg和补体受体（C3）的联合数据。结果显示，B细胞淋巴瘤可根据表面标志物表达分为不同的免疫亚群。一些组织学亚组（弥漫性中心母细胞/中心细胞型、中心细胞型、免疫细胞瘤）（基尔分类法）仅包含少数免疫亚型，而其他亚组则更为异质性（滤泡性中心母细胞/中心细胞型、中心母细胞型、淋巴细胞型）。通过结合免疫和组织学亚组，可识别出40多种表型；这种多样性很可能反映了B细胞区室的异质性。作为同一研究的一部分，还检测了细胞标志物表型的预后意义。对149/178例患者进行的生存分析未发现重链或轻链表达类型、C3受体表达与临床结局之间存在任何显著关系。我们的数据不支持近期关于免疫表型类型可能具有预后意义的研究发现。
