Gold E J, Mertelsmann R H, Filippa D A, Szatrowski T H, Koziner B, Clarkson B
Blood. 1983 Jul;62(1):107-11.
As part of a larger study to determine the prognostic significance of cell marker phenotype in diffuse lymphomas, 51 patients with monoclonal B-cell lymphoma were further characterized by receptors for C3 (EAC rosettes) as well as heavy and light chain phenotypes. Patients with greater than 10% EAC rosette-forming cells were found to have a statistically significant longer survival than those with less than 10% EAC rosettes (p = 0.005). A similar trend in survival duration was found for patients whose cells expressed mu heavy chain on their surfaces when compared to those with gamma heavy chain on their cell surfaces (p = 0.05). No difference was observed for light chain phenotype. No correlation was observed between these prognostic groups and any of the three most frequently used histologic classifications (i.e., Rappaport, Lukes, Kiel).
作为一项关于确定细胞标志物表型在弥漫性淋巴瘤中的预后意义的大型研究的一部分，51例单克隆B细胞淋巴瘤患者通过C3受体（EAC玫瑰花结）以及重链和轻链表型进行了进一步特征分析。发现EAC玫瑰花结形成细胞大于10%的患者，其生存期在统计学上显著长于EAC玫瑰花结小于10%的患者（p = 0.005）。与细胞表面表达γ重链的患者相比，细胞表面表达μ重链的患者在生存时间上也有类似趋势（p = 0.05）。轻链表型未观察到差异。在这些预后组与三种最常用的组织学分类（即Rappaport、Lukes、Kiel）之间未观察到相关性。
