Daeschner C W, Carpentieri U, Goldman A S, Haggard M E
Scand J Haematol. 1985 Aug;35(2):186-90. doi: 10.1111/j.1600-0609.1985.tb01569.x.
A relationship between zinc deficiency and lymphocyte function in children with sickle cell disease (SCD) has been suggested. Number and function of B and T lymphocytes were assessed in 3 matched groups of children: normal subjects with Hb A and normal zinc; patients with SCD; and normal zinc (SCD-N); and patients with SCD and decreased zinc (SCD-D). Percentages of B and T cells, response to cutaneous antigens and increases in tetanus antibody titres were similar among all groups. Absolute numbers of WBC, lymphocytes and B and T cells were markedly increased in SCD-N (p less than 0.001) and to a lesser degree in SCD-D (p less than 0.01). Controls and SCD-N had a normal response to all mitogens, which was not inhibited by SCD-D sera. SCD-D had a depressed response to PHA (p less than 0.001), which was not corrected by zinc addition in vitro. These findings indicate that B cell function and T cell-dependent delayed hypersensitivity are normal in children with SCD and are independent of body zinc status. They also suggest some abnormality of T helper cells in the presence of zinc deficiency, and in the absence of a demonstrable serum inhibitor.
有研究表明镰状细胞病（SCD）患儿的锌缺乏与淋巴细胞功能之间存在关联。对3组匹配的儿童进行了B淋巴细胞和T淋巴细胞数量及功能的评估：具有正常血红蛋白A和正常锌水平的正常受试者；患有SCD且锌水平正常的患者（SCD-N）；以及患有SCD且锌水平降低的患者（SCD-D）。所有组中B细胞和T细胞的百分比、对皮肤抗原的反应以及破伤风抗体滴度的增加情况相似。SCD-N组的白细胞、淋巴细胞以及B细胞和T细胞的绝对数量显著增加（p<0.001），SCD-D组的增加程度较小（p<0.01）。对照组和SCD-N组对所有有丝分裂原均有正常反应，且不受SCD-D组血清的抑制。SCD-D组对植物血凝素（PHA）的反应降低（p<0.001），体外添加锌后并未得到纠正。这些发现表明，SCD患儿的B细胞功能和T细胞依赖性迟发型超敏反应正常，且与机体锌状态无关。研究还提示，在存在锌缺乏且无明显血清抑制剂的情况下，T辅助细胞存在某些异常。
