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全面分析 TBC1Ds 在人肝细胞癌中的致癌和预后作用。

A comprehensive analysis of the oncogenic and prognostic role of TBC1Ds in human hepatocellular carcinoma.

机构信息

The Affiliated Geriatric Hospital of Nanjing Medical University, Nanjing, China.

出版信息

PeerJ. 2024 May 14;12:e17362. doi: 10.7717/peerj.17362. eCollection 2024.

DOI:10.7717/peerj.17362
PMID:38766486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11100476/
Abstract

BACKGROUNDS

TBC1D family members (TBC1Ds) are a group of proteins that contain the Tre2-Bub2-Cdc16 (TBC) domain. Recent studies have shown that TBC1Ds are involved in tumor growth, but no analysis has been done of expression patterns and prognostic values of TBC1Ds in hepatocellular carcinoma (HCC).

METHODS

The expression levels of TBC1Ds were evaluated in HCC using the TIMER, UALCN and Protein Atlas databases. The correlation between the mRNA levels of TBC1Ds and the prognosis of patients with HCC in the GEPIA database was then analyzed. An enrichment analysis then revealed genes that potentially interact with TBC1Ds. The correlation between levels of TBC1Ds and tumor-infiltrating immune cells (TIICs) in HCC were studied using the TIMER 2.0 database. Finally, a series of assays verified the role of TBC1Ds in HCC progression.

RESULTS

This study revealed the upregulated expression of TBC1Ds in HCC and the strong positive correlation between the mRNA levels of TBC1Ds and poor prognosis of patients with HCC. The functions of TBC1Ds were mainly related to autophagy and the AMPK pathway. There was also a significant correlation between level of TBC1Ds and tumor-infiltrating immune cells (TIICs) in HCC. The promoting role of TBC1Ds in HCC progression was verified assays.

CONCLUSION

The results of this analysis indicate that TBC1Ds may serve as new biomarkers for early diagnosis and treatment of HCC.

摘要

背景

TBC1D 家族成员（TBC1Ds）是一组含有 Tre2-Bub2-Cdc16（TBC）结构域的蛋白质。最近的研究表明，TBC1Ds 参与肿瘤生长，但尚未分析 TBC1Ds 在肝细胞癌（HCC）中的表达模式和预后价值。

方法

使用 TIMER、UALCN 和 Protein Atlas 数据库评估 HCC 中 TBC1D 的表达水平。然后分析 GEPIA 数据库中 TBC1D mRNA 水平与 HCC 患者预后的相关性。接着进行富集分析，揭示可能与 TBC1D 相互作用的基因。使用 TIMER 2.0 数据库研究 TBC1D 水平与 HCC 中肿瘤浸润免疫细胞（TIIC）的相关性。最后，一系列实验验证了 TBC1D 在 HCC 进展中的作用。

结果

本研究揭示了 HCC 中 TBC1D 的上调表达，以及 TBC1D mRNA 水平与 HCC 患者不良预后之间的强烈正相关。TBC1D 的功能主要与自噬和 AMPK 途径有关。TBC1D 水平与 HCC 中肿瘤浸润免疫细胞（TIIC）之间也存在显著相关性。实验验证了 TBC1D 在 HCC 进展中的促进作用。

结论

该分析结果表明，TBC1D 可能成为 HCC 早期诊断和治疗的新生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23f1/11100476/9501136e8210/peerj-12-17362-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23f1/11100476/9501136e8210/peerj-12-17362-g009.jpg
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本文引用的文献

1
TBC1D14 inhibits autophagy to suppress lymph node metastasis in head and neck squamous cell carcinoma by downregulating macrophage erythroblast attacher.TBC1D14 通过下调巨噬细胞红细胞生成素受体抑制自噬从而抑制头颈部鳞状细胞癌的淋巴结转移。
Int J Biol Sci. 2022 Feb 7;18(5):1795-1812. doi: 10.7150/ijbs.68992. eCollection 2022.
2
Rab2A regulates the progression of nonalcoholic fatty liver disease downstream of AMPK-TBC1D1 axis by stabilizing PPARγ.Rab2A 通过稳定 PPARγ 调节 AMPK-TBC1D1 轴下游的非酒精性脂肪性肝病进展。
PLoS Biol. 2022 Jan 21;20(1):e3001522. doi: 10.1371/journal.pbio.3001522. eCollection 2022 Jan.
3
Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy.
肝细胞 p62 抑制 mTORC1 激活和自噬缺陷的小鼠肝脏中的胆小管反应和肿瘤发生。
J Hepatol. 2022 Mar;76(3):639-651. doi: 10.1016/j.jhep.2021.10.014. Epub 2021 Oct 25.
4
The multifaceted regulation of mitophagy by endogenous metabolites.内源性代谢物对自噬的多方面调控。
Autophagy. 2022 Jun;18(6):1216-1239. doi: 10.1080/15548627.2021.1975914. Epub 2021 Sep 29.
5
Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1.收缩介导的骨骼肌葡萄糖转运受 AMPK、TBC1D1/4 和 Rac1 框架调节。
Diabetes. 2021 Dec;70(12):2796-2809. doi: 10.2337/db21-0587. Epub 2021 Sep 24.
6
Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.通过调节小分子 GTP 酶 Rab40 来调节脂质稳态，从而促进脂噬作用。
Cell Rep. 2021 Aug 31;36(9):109541. doi: 10.1016/j.celrep.2021.109541.
7
An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation.葡萄糖饥饿时 AMPK-ULK1-PIKFYVE 信号轴调控 PtdIns5P 依赖的自噬
Autophagy. 2021 Oct;17(10):2663-2664. doi: 10.1080/15548627.2021.1959240. Epub 2021 Aug 9.
8
The therapeutic implications of immunosuppressive tumor aerobic glycolysis.免疫抑制性肿瘤有氧糖酵解的治疗意义。
Cell Mol Immunol. 2022 Jan;19(1):46-58. doi: 10.1038/s41423-021-00727-3. Epub 2021 Jul 8.
9
HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness.HDAC11 通过 LKB1/AMPK 信号通路调控糖酵解以维持肝癌干细胞干性。
Cancer Res. 2021 Apr 15;81(8):2015-2028. doi: 10.1158/0008-5472.CAN-20-3044. Epub 2021 Feb 18.
10
The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.RabGAPs TBC1D1 和 TBC1D4 通过脂肪酸转运蛋白 SLC27A4/FATP4 控制长链脂肪酸进入骨骼肌的摄取。
Diabetes. 2020 Nov;69(11):2281-2293. doi: 10.2337/db20-0180. Epub 2020 Aug 31.