Tripathi Anuja, Park Jaeyoung, Pho Thomas, Champion Julie A
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 950 Atlantic Drive, Atlanta, Georgia, 30332, USA.
Small. 2024 Sep;20(38):e2311546. doi: 10.1002/smll.202311546. Epub 2024 May 20.
Bacterial adhesion to stainless steel, an alloy commonly used in shared settings, numerous medical devices, and food and beverage sectors, can give rise to serious infections, ultimately leading to morbidity, mortality, and significant healthcare expenses. In this study, Cu-coated nanotextured stainless steel (nSS) fabrication have been demonstrated using electrochemical technique and its potential as an antibiotic-free biocidal surface against Gram-positive and negative bacteria. As nanotexture and Cu combine for dual methods of killing, this material should not contribute to drug-resistant bacteria as antibiotic use does. This approach involves applying a Cu coating on nanotextured stainless steel, resulting in an antibacterial activity within 30 min. Comprehensive characterization of the surface revealing that the Cu coating consists of metallic Cu and oxidized states (Cu and Cu), has been performed by this study. Cu-coated nSS induces a remarkable reduction of 97% in Gram-negative Escherichia coli and 99% Gram-positive Staphylococcus epidermidis bacteria. This material has potential to be used to create effective, scalable, and sustainable solutions to prevent bacterial infections caused by surface contamination without contributing to antibiotic resistance.
细菌粘附于不锈钢（一种常用于公共场所、众多医疗设备以及食品和饮料行业的合金）会引发严重感染，最终导致发病、死亡以及高额的医疗费用。在本研究中，已证明采用电化学技术可制造出镀铜纳米纹理不锈钢（nSS），并展示了其作为一种对革兰氏阳性菌和阴性菌具有无抗生素杀菌作用的表面的潜力。由于纳米纹理和铜结合形成了双重杀菌方法，这种材料不应像使用抗生素那样导致耐药菌产生。该方法包括在纳米纹理不锈钢上涂覆铜涂层，从而在30分钟内产生抗菌活性。本研究对该表面进行了全面表征，结果表明铜涂层由金属铜及其氧化态（Cu⁺和Cu²⁺）组成。镀铜nSS能使革兰氏阴性大肠杆菌数量显著减少97%，革兰氏阳性表皮葡萄球菌数量显著减少99%。这种材料有潜力用于创造有效、可扩展且可持续的解决方案，以预防由表面污染引起的细菌感染，同时不会导致抗生素耐药性。
