Woo T Y, Rasmussen J E
Arch Dermatol. 1985 Nov;121(11):1403-5.
We investigated 24 juvenile cases of linear scleroderma for the presence of systemic disease and serologic abnormalities. Thirteen of 24 patients had antinuclear antibodies (ANA) at titers of 1:40 or greater. Rheumatoid factor (titers greater than or equal to 1:20) was detected in seven of 17 patients tested, five of whom also had ANA. Two of five patients with ANA and rheumatoid factor had systemic diseases, such as nephritis and Raynaud's phenomenon. One patient with ANA developed typical dermatomyositis. Consequently, patients with linear scleroderma may be at some risk for developing systemic collagen-vascular diseases. On initial presentation, patients with linear scleroderma should give a complete history and receive a thorough physical examination as well as undergo laboratory evaluations for the presence of ANA and rheumatoid factor. Long-term observation with periodic reevaluation is appropriate for many members of this group.
我们调查了24例青少年线状硬皮病患者，以确定是否存在系统性疾病和血清学异常。24例患者中有13例抗核抗体（ANA）滴度为1:40或更高。在17例接受检测的患者中，7例检测到类风湿因子（滴度大于或等于1:20），其中5例同时也有ANA。5例有ANA和类风湿因子的患者中有2例患有系统性疾病，如肾炎和雷诺现象。1例有ANA的患者发展为典型的皮肌炎。因此，线状硬皮病患者可能有发生系统性胶原血管疾病的风险。初次就诊时，线状硬皮病患者应提供完整病史，接受全面体格检查，并进行ANA和类风湿因子检测的实验室评估。对该组中的许多患者进行长期观察并定期重新评估是合适的。
