Unidad de Investigación. Centro Dermatológico Dr. Ladislao de la Pascua, Ciudad de México, México.
Bol Med Hosp Infant Mex. 2024;81(2):73-78. doi: 10.24875/BMHIM.23000083.
Vitiligo is a multifactorial disease characterized by the progressive loss of melanocytes. The worldwide prevalence ranges from 0.5% to 2%, and in children from 0% to 2.16%. The objective of this study was to determine the variables associated with progression of vitiligo.
A retrospective cohort was carried out where a random sample of records of pediatric patients with vitiligo from January 2016 to December 2020 was analyzed. The variables were studied: age at onset, sex, hereditary family history, personal history of thyroid diseases, time of evolution, classification, Köebner phenomena, mucosal vitiligo, halo nevus, premature graying and the presence of other dermatoses. The final state was classified as progression, stability, partial remission and complete remission.
574 children with vitiligo; 290 (50.5%) women, 284 (49.5%) men. Non-segmental vitiligo in 324 (56.4%), segmental vitiligo in 250 (43.6%). Mean age of onset 8.7 years (SD: 4.54). Median evolution time 6 months (25 percentile of 3 months and 75 percentile of 24 months). Family history 27 (4.70%). Thyroid disease 7 (1.21%). Evolution remained stable in 44 (7.7%), 68 (11.8%) had progression, 32 (5.6%) complete remission, 222 (38.7%) partial remission and 208 (36.2%) one consultation. Non-segmental vitiligo was obtained p < 0.028, younger age of onset p < 0.000, and none skin comorbidities p < 0.009.
The variables that were associated with a more progression were non-segmental vitiligo, early ages at the onset of the disease, and not presenting with other skin diseases.
白癜风是一种多因素疾病，其特征是黑色素细胞逐渐丧失。全球发病率为 0.5%至 2%，儿童发病率为 0%至 2.16%。本研究旨在确定与白癜风进展相关的变量。
进行了一项回顾性队列研究，对 2016 年 1 月至 2020 年 12 月期间患有白癜风的儿科患者的随机样本记录进行了分析。研究的变量包括发病年龄、性别、遗传家族史、甲状腺疾病个人史、发病时间、分类、柯氏现象、黏膜白癜风、晕痣、早生白发和其他皮肤病。最终状态分为进展、稳定、部分缓解和完全缓解。
共纳入 574 例白癜风患儿，其中女性 290 例（50.5%），男性 284 例（49.5%）；非节段性白癜风 324 例（56.4%），节段性白癜风 250 例（43.6%）；发病年龄平均 8.7 岁（标准差：4.54）；中位发病时间为 6 个月（25%分位数为 3 个月，75%分位数为 24 个月）；家族史 27 例（4.70%）；甲状腺疾病 7 例（1.21%）；44 例（7.7%）病情稳定，68 例（11.8%）病情进展，32 例（5.6%）完全缓解，222 例（38.7%）部分缓解，208 例（36.2%）仅就诊一次。非节段性白癜风（p < 0.028）、发病年龄较小（p < 0.000）、无其他皮肤疾病（p < 0.009）与更严重的疾病进展相关。
与更严重的疾病进展相关的变量是非节段性白癜风、发病年龄较小和无其他皮肤疾病。
