2023 年初中国 H1N1 流感病毒爆发的遗传特征。
Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023.
机构信息
College of Life Science and Technology, Xinjiang University, Urumchi, 830046, China; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
Suzhou Center for Disease Control and Prevention, Suzhou, 215004, China.
出版信息
Virol Sin. 2024 Jun;39(3):520-523. doi: 10.1016/j.virs.2024.05.003. Epub 2024 May 18.
• H1N1 strains were collected from Hunan and Jiangsu provinces in early 2023 following the optimized COVID-19 strategy. • Phylogenic analysis revealed that the epidemic H1N1 viruses fell into different HA clades compared to vaccine strains. • Mutations on HA antigenic sites suggest antigenic drift in the epidemic H1N1 viruses versus vaccine strains. • A potential mismatch was found between recommended vaccine strains and the epidemic H1N1 viruses. • The expeditious, precise, and personalized vaccine update program for influenza virus may need to be put on the agenda.
• 2023 年初，在中国优化 COVID-19 防控策略后，从湖南和江苏两省收集了 H1N1 毒株。 • 系统进化分析显示，流行的 H1N1 病毒与疫苗株相比，属于不同的 HA 分支。 • HA 抗原位点的突变表明，流行的 H1N1 病毒相对于疫苗株发生了抗原漂移。 • 推荐的疫苗株与流行的 H1N1 病毒之间存在潜在的不匹配。 • 需要将流感病毒的快速、准确和个性化疫苗更新计划提上日程。
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