Jones G R, Mason W H, Fishman L S, DeClerck Y A
Cancer. 1985 Dec 15;56(12):2804-8. doi: 10.1002/1097-0142(19851215)56:12<2804::aid-cncr2820561216>3.0.co;2-d.
Primary central nervous system lymphoma is a rare presentation of lymphoma and is usually seen in adults, often in association with immunodeficiency. Evaluation of these patients classically shows discrete intracranial lesions, and long-term prognosis despite treatment is poor. The case of a child is presented who had no identifiable predisposing factors, no radiologic evidence of intracranial mass, no evidence of systemic disease, and in whom the diagnosis of primary CNS lymphoma was made based on documentation of a monoclonal population of malignant B-cells in the cerebrospinal fluid. The patient, in whom irreversible blindness developed, was treated with a combination of cranial radiation, and intrathecal and systemic chemotherapy, and is currently alive and disease-free 15 months after diagnosis.
原发性中枢神经系统淋巴瘤是淋巴瘤的一种罕见表现形式，通常见于成年人，常与免疫缺陷相关。对这些患者的评估典型地显示出离散的颅内病变，并且尽管进行了治疗，长期预后仍很差。本文介绍了一例儿童病例，该患儿没有可识别的诱发因素，没有颅内肿块的放射学证据，没有全身性疾病的证据，并且根据脑脊液中恶性B细胞单克隆群体的记录确诊为原发性中枢神经系统淋巴瘤。该患者出现了不可逆的失明，接受了头颅放疗、鞘内化疗和全身化疗的联合治疗，目前在诊断后15个月仍存活且无疾病。
