Neu H C, Chin N X
Chemioterapia. 1985 Aug;4(4):271-7.
The in vitro activity of cefotetan was assessed against beta-lactamase producing clinical isolates. The majority of Enterobacteriaceae were inhibited by less than or equal to 8 micrograms/ml with 50% of isolates inhibited by less than or equal to 1 microgram/ml. Cefotetan inhibited organisms resistant to cefazolin, cefonicid and cefoperazone, but not isolates of Enterobacter, Citrobacter or Serratia resistant to ceftizoxime. Cefotetan inhibited beta-lactamase producing Haemophilus influenzae and Neisseria gonorrhoeae at less than or equal to 1 microgram/ml, but it did not inhibit Acinetobacter or Pseudomonas aeruginosa. Cefotetan was as active as cefoxitin against anaerobic species such as Bacteroides fragilis and Clostridium. Cefotetan was not hydrolyzed by Richmond-Sykes plasmid beta-lactamases of type III such as TEM and SHV, nor by the OXA or PSE beta-lactamases. It also was not hydrolyzed by cephalosporinases of Richmond-Sykes type Ia or Id. Cefotetan inhibited beta-lactamases of the type Ia and Id, but it also induced these beta-lactamases in P. aeruginosa, E. cloacae and C. freundii.
对头孢替坦的体外活性进行了评估，以检测其对产β-内酰胺酶的临床分离株的作用。大多数肠杆菌科细菌在浓度小于或等于8微克/毫升时受到抑制，50%的分离株在浓度小于或等于1微克/毫升时受到抑制。头孢替坦对耐头孢唑林、头孢尼西和头孢哌酮的菌株有抑制作用，但对耐头孢噻肟的阴沟肠杆菌、柠檬酸杆菌或沙雷菌分离株无抑制作用。头孢替坦在浓度小于或等于1微克/毫升时可抑制产β-内酰胺酶的流感嗜血杆菌和淋病奈瑟菌，但对不动杆菌或铜绿假单胞菌无抑制作用。头孢替坦对脆弱拟杆菌和梭菌等厌氧菌的活性与头孢西丁相当。头孢替坦不会被III型里士满-赛克斯质粒β-内酰胺酶（如TEM和SHV）水解，也不会被OXA或PSEβ-内酰胺酶水解。它也不会被里士满-赛克斯Ia型或Id型头孢菌素酶水解。头孢替坦可抑制Ia型和Id型β-内酰胺酶，但也会在铜绿假单胞菌、阴沟肠杆菌和弗氏柠檬酸杆菌中诱导这些β-内酰胺酶的产生。
