Ling G V, Ruby A L
J Am Vet Med Assoc. 1979 Sep 1;175(5):480-1.
Gentamicin was administered parenterally for 6 days to 43 dogs with urinary tract infections. The daily dosage of 6.6 mg/kg (3 mg/lb) was divided into equal parts and given IM or SC at 8-hour intervals. Dogs selected for treatment with gentamicin had urinary infections that had not responded to treatment with other antimicrobial agents or had bacterial isolates from urine that were resistant to several antimicrobial agents on in vitro susceptibility tests. Response to treatment, defined as negative urine culture on the last day of therapy or 4 to 14 days after completion of the therapeutic course, included 20 of 22 (91%) infections caused by Escherichia coli, 8 of 9 (89%) infections caused by Kebsiella pneumoniae, 6 of 7 (86%) infections caused by Proteus spp, and 6 of 7 infections caused by Pseudomonas spp. These four species comprised 84% of the bacteria isolated from the dogs in this study.
对43只患有尿路感染的犬只进行了为期6天的庆大霉素非肠道给药。每日剂量为6.6毫克/千克（3毫克/磅），分为等量剂量，每8小时肌肉注射或皮下注射一次。选择用庆大霉素治疗的犬只，其尿路感染对其他抗菌药物治疗无反应，或尿液中的细菌分离株在体外药敏试验中对多种抗菌药物耐药。治疗反应定义为治疗最后一天或治疗疗程结束后4至14天尿液培养呈阴性，其中由大肠杆菌引起的22例感染中有20例（91%）、由肺炎克雷伯菌引起的9例感染中有8例（89%）、由变形杆菌属引起的7例感染中有6例（86%）以及由假单胞菌属引起的7例感染中有6例出现治疗反应。这四个菌种占本研究中从犬只分离出的细菌的84%。
