Ahrens Misha B, Khakh Baljit S, Poskanzer Kira E
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
Department of Physiology and Department of Neurobiology, University of California Los Angeles, Los Angeles, California 90095, USA
Cold Spring Harb Perspect Biol. 2024 Oct 1;16(10):a041353. doi: 10.1101/cshperspect.a041353.
Astrocytes are predominant glial cells that tile the central nervous system and participate in well-established functional and morphological interactions with neurons, blood vessels, and other glia. These ubiquitous cells display rich intracellular Ca signaling, which has now been studied for over 30 years. In this review, we provide a summary and perspective of recent progress concerning the study of astrocyte intracellular Ca signaling as well as discussion of its potential functions. Progress has occurred in the areas of imaging, silencing, activating, and analyzing astrocyte Ca signals. These insights have collectively permitted exploration of the relationships of astrocyte Ca signals to neural circuit function and behavior in a variety of species. We summarize these aspects along with a framework for mechanistically interpreting behavioral studies to identify directly causal effects. We finish by providing a perspective on new avenues of research concerning astrocyte Ca signaling.
星形胶质细胞是中枢神经系统中占主导地位的神经胶质细胞，它们覆盖整个中枢神经系统，并与神经元、血管及其他神经胶质细胞进行已被充分证实的功能和形态学相互作用。这些普遍存在的细胞表现出丰富的细胞内钙信号，目前对其研究已超过30年。在本综述中，我们总结并展望了星形胶质细胞内钙信号研究的最新进展，并讨论了其潜在功能。在成像、沉默、激活和分析星形胶质细胞钙信号方面均取得了进展。这些见解共同促进了对多种物种中星形胶质细胞钙信号与神经回路功能及行为之间关系的探索。我们总结了这些方面，并提供了一个用于机械性解释行为学研究以直接确定因果效应的框架。最后，我们展望了关于星形胶质细胞钙信号研究的新途径。
