Biopharmaceuticals Lab, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, 603 203, Tamilnadu, India.
Inflamm Res. 2024 Jul;73(7):1203-1221. doi: 10.1007/s00011-024-01893-6. Epub 2024 May 21.
Inflammation serves as our body's immune response to combat infections, pathogens, viruses, and external stimuli. Inflammation can be classified into two types: acute inflammation and chronic inflammation. Non-steroidal anti-inflammatory medications (NSAIDs) are used to treat both acute and chronic inflammatory disorders. However, these treatments have various side effects such as reduced healing efficiency, peptic ulcers, gastrointestinal toxicities, etc. METHOD: This review assesses the potential of anti-inflammatory peptides (AIPs) derived from various natural sources, such as algae, fungi, plants, animals, and marine organisms. Focusing on peptides rich in cysteines and methionine, sulphur-containing amino acids known for their role in suppression of inflammation.
Due to their varied biological activity, ability to penetrate cells, and low cytotoxicity, bioactive peptides have garnered interest as possible therapeutic agents. The utilisation of AIPs has shown great potential in the treatment of disorders associated with inflammation. AIPs can be obtained from diverse natural sources such as algae, fungi, plants, and animals. Cysteine and methionine are sulphur-containing amino acids that aid in the elimination of free radicals, hence assisting in the treatment of inflammatory diseases.
This review specifically examines several sources of AIPs including peptides that contain numerous cysteines and methionine. In addition, the biological characteristics of these amino acids and advancements in peptide delivery are also discussed.
炎症是我们身体对感染、病原体、病毒和外部刺激的免疫反应。炎症可分为两种类型：急性炎症和慢性炎症。非甾体抗炎药（NSAIDs）用于治疗急性和慢性炎症性疾病。然而，这些治疗方法有各种副作用，如愈合效率降低、胃溃疡、胃肠道毒性等。方法：本综述评估了来自各种天然来源的抗炎肽（AIPs）的潜力，如藻类、真菌、植物、动物和海洋生物。重点是富含半胱氨酸和蛋氨酸的肽，这些含硫氨基酸因其在抑制炎症方面的作用而闻名。结果：由于其多样的生物学活性、穿透细胞的能力和低细胞毒性，生物活性肽作为潜在的治疗剂引起了人们的兴趣。AIP 在治疗与炎症相关的疾病方面显示出巨大的潜力。AIP 可从多种天然来源获得，如藻类、真菌、植物和动物。半胱氨酸和蛋氨酸是含硫氨基酸，有助于清除自由基，因此有助于治疗炎症性疾病。结论：本综述特别研究了几种 AIP 的来源，包括含有大量半胱氨酸和蛋氨酸的肽。此外，还讨论了这些氨基酸的生物学特性和肽传递的进展。
