Melamed E, Rosenthal J, Cohen O, Globus M, Uzzan A
Eur J Pharmacol. 1985 Oct 8;116(1-2):179-81. doi: 10.1016/0014-2999(85)90201-8.
Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP+) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.
多巴胺再摄取抑制剂诺米芬辛与MPTP联合给药可完全预防MPTP诱导的小鼠纹状体多巴胺长期（治疗后30天）耗竭。分别与去甲丙咪嗪、氯米帕明或氟西汀（去甲肾上腺素和5-羟色胺抑制剂）共同治疗对MPTP的多巴胺神经毒性没有影响。这些发现表明，MPTP（或MPP+）是特定多巴胺再摄取系统的底物，这可能部分解释了其对多巴胺能神经元的选择性毒性作用。
