Melamed E, Rosenthal J, Cohen O, Uzzan A, Globus M
Neuropharmacology. 1985 Sep;24(9):923-5. doi: 10.1016/0028-3908(85)90047-4.
In mice, long-term reductions in striatal DA produced by the neurotoxin MPTP were completely prevented by its combined administration with amphetamine. Depletion of DA from DA terminals by cotreatment with reserpine did not suppress but rather enhanced MPTP-induced DA decrements in striatum. Amphetamine protection against DA neurotoxicity of MPTP in mice is probably not due to increases in DA release and may be related to inhibition of MPTP transport into nigrostriatal terminals via the DA reuptake system.
在小鼠中，神经毒素MPTP导致的纹状体多巴胺（DA）长期减少可通过与苯丙胺联合给药而完全预防。与利血平共同处理使DA末梢的DA耗竭，这并未抑制反而增强了MPTP诱导的纹状体DA减少。苯丙胺对小鼠MPTP所致DA神经毒性的保护作用可能并非由于DA释放增加，可能与通过DA再摄取系统抑制MPTP转运至黑质纹状体末梢有关。
