Somaiya Institute for Research and Consultancy, Somaiya Vidyavihar University, Vidyavihar (E), Mumbai, India.
J Biochem Mol Toxicol. 2024 Jun;38(6):e23732. doi: 10.1002/jbt.23732.
Achieving targeted, customized, and combination therapies with clarity of the involved molecular pathways is crucial in the treatment as well as overcoming multidrug resistance (MDR) in cancer. Nanotechnology has emerged as an innovative and promising approach to address the problem of drug resistance. Developing nano-formulation-based therapies using therapeutic agents poses a synergistic effect to overcome MDR in cancer. In this review, we aimed to highlight the important pathways involved in the progression of MDR in cancer mediated through nanotechnology-based approaches that have been employed to circumvent them in recent years. Here, we also discussed the potential use of marine metabolites to treat MDR in cancer, utilizing active drug-targeting nanomedicine-based techniques to enhance selective drug accumulation in cancer cells. The discussion also provides future insights for developing complex targeted, multistage responsive nanomedical drug delivery systems for effective cancer treatments. We propose more combinational studies and their validation for the possible marine-based nanoformulations for future development.
在癌症治疗中以及克服多药耐药性（MDR）方面，通过明确涉及的分子途径实现靶向、定制和联合治疗至关重要。纳米技术已成为解决耐药性问题的一种创新和有前途的方法。使用治疗剂开发基于纳米制剂的疗法具有协同作用，可以克服癌症中的 MDR。在这篇综述中，我们旨在强调通过基于纳米技术的方法介导的癌症中 MDR 进展涉及的重要途径，这些方法近年来已被用于规避它们。在这里，我们还讨论了利用海洋代谢物治疗癌症中的 MDR 的潜在用途，利用主动药物靶向纳米医学技术来增强药物在癌细胞中的选择性积累。讨论还为开发用于有效癌症治疗的复杂靶向、多阶段响应性纳米医学药物输送系统提供了未来的见解。我们建议进行更多的组合研究及其验证，以开发未来可能的基于海洋的纳米制剂。
