Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, PR China.
Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological & Chemical engineering, Chongqing University of Education, Chongqing, PR China.
Gut Microbes. 2024 Jan-Dec;16(1):2356284. doi: 10.1080/19490976.2024.2356284. Epub 2024 May 20.
Inflammatory bowel disease (IBD) is a chronic and recurrent condition affecting the gastrointestinal tract. Disturbed gut microbiota and abnormal bile acid (BA) metabolism are notable in IBD, suggesting a bidirectional relationship. Specifically, the diversity of the gut microbiota influences BA composition, whereas altered BA profiles can disrupt the microbiota. IBD patients often exhibit increased primary bile acid and reduced secondary bile acid concentrations due to a diminished bacteria population essential for BA metabolism. This imbalance activates BA receptors, undermining intestinal integrity and immune function. Consequently, targeting the microbiota-BA axis may rectify these disturbances, offering symptomatic relief in IBD. Here, the interplay between gut microbiota and bile acids (BAs) is reviewed, with a particular focus on the role of gut microbiota in mediating bile acid biotransformation, and contributions of the gut microbiota-BA axis to IBD pathology to unveil potential novel therapeutic avenues for IBD.
炎症性肠病（IBD）是一种影响胃肠道的慢性复发性疾病。肠道微生物群紊乱和胆汁酸（BA）代谢异常在 IBD 中很明显，表明它们之间存在双向关系。具体来说，肠道微生物群的多样性影响 BA 组成，而改变的 BA 谱可以破坏微生物群。由于代谢 BA 所必需的细菌种群减少，IBD 患者通常表现出初级胆汁酸增加和次级胆汁酸浓度降低。这种不平衡会激活 BA 受体，破坏肠道完整性和免疫功能。因此，靶向微生物群-BA 轴可能纠正这些紊乱，为 IBD 提供症状缓解。在这里，我们回顾了肠道微生物群和胆汁酸（BAs）之间的相互作用，特别关注肠道微生物群在介导胆汁酸生物转化中的作用，以及肠道微生物群-BA 轴对 IBD 病理学的贡献，以揭示 IBD 的潜在新治疗途径。
