Chandrasiri Nayana, Taiwo Oluwatosin, Ahmed Muneer, Malhotra Anmol, El-Sheikh Soha
Department of Cellular Pathology, Royal Free London Foundation Trust, London, UK.
The Centre for Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.
J Breast Cancer. 2024 Jun;27(3):215-222. doi: 10.4048/jbc.2024.0054. Epub 2024 May 7.
Breast implant augmentation is a low-risk procedure with few life-threatening complications, most commonly rupture or leakage and contraction of the capsule. Breast implant-associated (BIA) malignancies are rare. Anaplastic large cell lymphoma (ALCL) is the most well-known neoplastic condition associated with breast augmentation. Carcinomas arising in association with implants have been reported but are rarer than ALCL. BIA-mesenchymal tumors are extremely rare and most are locally aggressive fibromatosis. To date, only eight cases of BIA sarcomas have been reported. Herein, we describe a case of silicone BIA-undifferentiated pleomorphic sarcoma (UPS) that was initially mistaken for ALCL because of a significant clinical and radiological overlap in presentation and imaging. Here, we present the morphological and molecular features of this rare neoplasm. We reviewed the existing literature related to BIA sarcomas to highlight the importance of considering this diagnosis in cases of recurrent ALCL-negative BIA effusions.
隆胸手术是一种低风险的手术，几乎没有危及生命的并发症，最常见的是破裂、渗漏和包膜挛缩。与乳房植入物相关的（BIA）恶性肿瘤很少见。间变性大细胞淋巴瘤（ALCL）是与隆胸最相关的肿瘤疾病。与植入物相关的癌症已有报道，但比ALCL更罕见。BIA间充质肿瘤极为罕见，大多数是局部侵袭性纤维瘤病。迄今为止，仅报道了8例BIA肉瘤病例。在此，我们描述了一例硅胶BIA未分化多形性肉瘤（UPS），由于其临床表现和影像学上存在显著重叠，最初被误诊为ALCL。在此，我们展示了这种罕见肿瘤的形态学和分子特征。我们回顾了与BIA肉瘤相关的现有文献，以强调在复发性ALCL阴性的BIA积液病例中考虑这一诊断的重要性。
