Adelson Miriam, Smith Dinita, Sason Anat, Duff Sherry, Renteria Ana, Schreiber Shaul, Peles Einat
Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse, Treatment & Research Las Vegas, Nevada, USA.
Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse, Treatment & Research, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
J Addict Dis. 2025 Apr-Jun;43(2):162-167. doi: 10.1080/10550887.2024.2353432. Epub 2024 May 20.
Patients in methadone maintenance treatment (MMT) may develop age-related medical problems. Objective: To compare hypertension prevalence and its risk factors between two MMT clinics, having similar treatment guidelines, but different characteristics, one from Tel Aviv (TA) and one from Las Vegas (LV).
Prevalence of hypertension (systolic ≥140 and or diastolic ≥90 mmHg BP) among all current 291 MMT patients in TA and 180 patients in LV were studied, including body mass index (BMI), drugs in urine, sociodemographic, and addiction history data.
Hypertension prevalence was comparable in TA (35.4%) and LV (34.4%), however TA patients were older (55.9 ± 9.5 vs. 45.5 ± 13.3, < 0.001), with fewer females (22 vs. 42.2%, < 0.001), fewer obese (BMI ≥30) (24 vs. 40.9%, < 0.001), higher cocaine (21 vs. 7.8%, < 0.001), and lower cannabis (14.1 vs. 32.4%, < 0.001) and amphetamines (0 vs. 33.5%) users. Logistic regression found higher BMI to characterize hypertension in both clinics, but in TA also negative urine cocaine, benzodiazepine, and opioids screen, while in LV older age (≥50 y), male gender, and negative urine cannabis screen.
While TA was characterized with older patients, LV patients had a comparable hypertension rate, as obesity was more prevalent. No drug use was accompanied by higher BMI in TA and therefore associated with hypertension. Weight reduction, hypertension detection and treatment are recommended.
接受美沙酮维持治疗（MMT）的患者可能会出现与年龄相关的医疗问题。目的：比较两家MMT诊所的高血压患病率及其危险因素，这两家诊所治疗指南相似，但特点不同，一家位于特拉维夫（TA），另一家位于拉斯维加斯（LV）。
研究了TA目前的291名MMT患者和LV的180名患者中高血压（收缩压≥140和/或舒张压≥90 mmHg）的患病率，包括体重指数（BMI）、尿液中的药物、社会人口统计学和成瘾史数据。
TA（35.4%）和LV（34.4%）的高血压患病率相当，然而TA患者年龄更大（55.9±9.5岁对45.5±13.3岁，P<0.001），女性更少（22%对42.2%，P<0.001），肥胖者（BMI≥30）更少（24%对40.9%，P<0.001），可卡因使用者更多（21%对7.8%，P<0.001），大麻使用者更少（14.1%对32.4%，P<0.001），苯丙胺使用者更少（0对33.5%）。逻辑回归发现，较高的BMI是两家诊所高血压的特征，但在TA中，尿液可卡因、苯二氮䓬和阿片类药物筛查呈阴性也是特征，而在LV中，年龄较大（≥50岁）、男性以及尿液大麻筛查呈阴性是特征。
虽然TA以老年患者为特征，但LV患者的高血压发生率相当，因为肥胖更为普遍。在TA中，无药物使用伴随着较高的BMI，因此与高血压相关。建议减轻体重、检测和治疗高血压。
