Cutler Bradley, Haesemeyer Martin
Graduate program in Molecular, Cellular and Developmental Biology, Columbus, Ohio, United States.
The Ohio State University, Columbus, Ohio, United States.
Neurophotonics. 2024 Jul;11(3):033409. doi: 10.1117/1.NPh.11.3.033409. Epub 2024 May 20.
Thermoregulation is critical for survival across species. In animals, the nervous system detects external and internal temperatures, integrates this information with internal states, and ultimately forms a decision on appropriate thermoregulatory actions. Recent work has identified critical molecules and sensory and motor pathways controlling thermoregulation. However, especially with regard to behavioral thermoregulation, many open questions remain. Here, we aim to both summarize the current state of research, the "knowledge," as well as what in our mind is still largely missing, the "future directions." Given the host of circuit entry points that have been discovered, we specifically see that the time is ripe for a neuro-computational perspective on thermoregulation. Such a perspective is largely lacking but is increasingly fueled and made possible by the development of advanced tools and modeling strategies.
体温调节对于所有物种的生存至关重要。在动物中，神经系统检测外部和内部温度，将这些信息与内部状态整合起来，并最终就适当的体温调节行动做出决策。最近的研究已经确定了控制体温调节的关键分子以及感觉和运动通路。然而，特别是在行为体温调节方面，仍然存在许多悬而未决的问题。在这里，我们旨在总结当前的研究现状，即“知识”，以及我们认为在很大程度上仍然缺失的东西，即“未来方向”。鉴于已经发现了众多的神经回路切入点，我们特别认为，从神经计算的角度研究体温调节的时机已经成熟。这样的观点目前在很大程度上还不存在，但先进工具和建模策略的发展正日益推动并使之成为可能。
