Patil M S, Locher S E, Hariharan P V
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Nov;48(5):691-700. doi: 10.1080/09553008514551791.
The extent of production and excision repair of 5,6-dihydroxydihydrothymine type base (t') damage was determined in transcriptionally active and inactive chromatin of HeLa cells after exposure to 6.8 MeV electrons. It was observed that not only the yield but also rate of repair of t' products was greater in the active chromatin compared to the inactive chromatin of HeLa cells. The results strongly indicate that the conformation of chromatin is an important factor in determining the sensitivity to radiation damage and accessibility to enzymes required for repair of such damage.
在暴露于6.8 MeV电子后，测定了HeLa细胞转录活性和非活性染色质中5,6 - 二羟基二氢胸腺嘧啶型碱基（t'）损伤的产生和切除修复程度。观察到，与HeLa细胞的非活性染色质相比，活性染色质中t'产物的产量和修复速率都更高。结果有力地表明，染色质的构象是决定对辐射损伤的敏感性以及对修复此类损伤所需酶的可及性的重要因素。
