Wu Sha, Zheng Caiping, Liu Nannan, Deng Tingting, Wang Jie, Qi Luming, Xia Lina
State Administration of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medicine Regimen and Health, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Cardiovasc Med. 2023 Jan 25;10:1075084. doi: 10.3389/fcvm.2023.1075084. eCollection 2023.
Liuzijue training (LZJ) is a traditional exercise integrating breathing meditation and physical exercise, which could prevent and improve hypertension symptoms.
We aimed to evaluate the therapeutic effect of LZJ on hypertensive patients from the perspectives of blood pressure (BP), vascular endothelial function, immune homeostasis, and gut microbiota.
We conducted a randomized, controlled, single-blind experiment to assess the effect of 12 weeks LZJ in hypertensive patients. We measured the blood pressure level, vascular endothelial function, serum inflammatory factor concentration, and fecal microbial composition of hypertension patients.
Compared with aerobic training, LZJ has a more significant effect on serum inflammatory factors (IL-6 and IL-10) and gut microbiota. PCoA analysis showed that LZJ tended to transform the gut microbiota structure of hypertensive subjects into that of healthy people. This process involves significant changes in Bacteroides, Clostridium_sensu_stricto_1, Escherichia-Shigella, Haemophilus, Megamonas, and Parabacteroides. In particular, Bacteroides and Escherichia-Shigella, these bacteria were closely related to the improvement of BP in hypertensive patients.
In conclusion, our results confirm that LZJ could be used as an adjuvant treatment for hypertensive patients, which could effectively reduce BP, improve the immune homeostasis and gut microbiota structure in patients, and provide a theoretical reference for the use of LZJ in the clinic.
http://www.chictr.org.cn/listbycreater.aspx, identifier: ChiCTR2200066269.
六字诀训练（LZJ）是一种融合呼吸冥想与体育锻炼的传统运动，可预防和改善高血压症状。
我们旨在从血压（BP）、血管内皮功能、免疫稳态和肠道微生物群的角度评估六字诀训练对高血压患者的治疗效果。
我们进行了一项随机、对照、单盲实验，以评估12周六字诀训练对高血压患者的影响。我们测量了高血压患者的血压水平、血管内皮功能、血清炎症因子浓度和粪便微生物组成。
与有氧运动训练相比，六字诀训练对血清炎症因子（IL-6和IL-10）和肠道微生物群有更显著的影响。主坐标分析表明，六字诀训练倾向于将高血压受试者的肠道微生物群结构转变为健康人的结构。这个过程涉及拟杆菌属、严格梭菌1群、埃希氏菌-志贺氏菌属、嗜血杆菌属、巨单胞菌属和副拟杆菌属的显著变化。特别是，拟杆菌属和埃希氏菌-志贺氏菌属，这些细菌与高血压患者血压的改善密切相关。
总之，我们的结果证实六字诀训练可作为高血压患者的辅助治疗方法，它可以有效降低血压，改善患者的免疫稳态和肠道微生物群结构，并为六字诀训练在临床上的应用提供理论参考。
http://www.chictr.org.cn/listbycreater.aspx，标识符：ChiCTR2200066269。
