Khan Khalid, Quazi Sabiha, Bankar Nandkishor J, Wanjari Anil, Gosavi Rajesh, Joshi Prashant, Gupta Sunil
Medicine, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Nagpur, IND.
Dermatology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Nagpur, IND.
Cureus. 2024 Apr 19;16(4):e58612. doi: 10.7759/cureus.58612. eCollection 2024 Apr.
The rising prevalence of insulin resistance (IR), obesity, and its complications in India is due to lifestyle changes, eating patterns, stress, and genetic factors. Markers for IR are often expensive, invasive, or impractical for use in economically disadvantaged or remote areas. To address this, we evaluated the efficacy of the triglyceride to high-density lipoprotein (TG/HDL) ratio as a simple, reliable, accessible, and affordable surrogate marker of IR in comparison to the homeostatic model assessment for insulin resistance (HOMA-IR).
This cross-sectional observational study was performed at a tertiary care center in central India and included 815 subjects aged 18 to 60 years after excluding those with systemic diseases, drugs affecting weight, or pregnant or lactating women. Descriptive and inferential statistical analysis was done to represent the study findings.
Males and obese subjects were more insulin resistant than females and non-obese subjects, respectively. The TG/HDL had a sensitivity of 91.81%, a specificity of 92.88%, a positive predictive value of 94.46%, and a negative predictive value of 89.56%, with a diagnostic accuracy of 92.27% when compared to HOMA-IR.
We concluded that TG/HDL serves as a simple, affordable, and accurate marker of IR in a diverse population of central India. There is a definite scope to use the same for large-scale screening, epidemiological research, and routine clinical practice.
在印度，胰岛素抵抗（IR）、肥胖及其并发症的患病率不断上升，这归因于生活方式的改变、饮食模式、压力和遗传因素。IR的标志物通常价格昂贵、具有侵入性，或者在经济条件较差或偏远地区使用不切实际。为了解决这个问题，我们评估了甘油三酯与高密度脂蛋白（TG/HDL）的比值作为IR的一种简单、可靠、可及且经济实惠的替代标志物的有效性，并与胰岛素抵抗的稳态模型评估（HOMA-IR）进行了比较。
这项横断面观察性研究在印度中部的一家三级医疗中心进行，纳入了815名年龄在18至60岁之间的受试者，排除了患有全身性疾病、影响体重的药物使用者或孕妇及哺乳期妇女。进行了描述性和推断性统计分析以呈现研究结果。
男性和肥胖受试者分别比女性和非肥胖受试者更具胰岛素抵抗性。与HOMA-IR相比，TG/HDL的敏感性为91.81%，特异性为92.88%，阳性预测值为94.46%，阴性预测值为89.56%，诊断准确性为92.27%。
我们得出结论，在印度中部的不同人群中，TG/HDL可作为一种简单、经济且准确的IR标志物。在大规模筛查、流行病学研究和常规临床实践中使用该标志物具有明确的应用范围。
