Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Nuffield Department of Surgical Sciences, University of Oxford, Oxford OX3 9DU, UK.
J Cell Sci. 2024 May 15;137(10). doi: 10.1242/jcs.260943. Epub 2024 May 21.
Membrane trafficking, a fundamental cellular process encompassing the transport of molecules to specific organelles, endocytosis at the plasma membrane and protein secretion, is crucial for cellular homeostasis and signalling. Cancer cells adapt membrane trafficking to enhance their survival and metabolism, and understanding these adaptations is vital for improving patient responses to therapy and identifying therapeutic targets. In this Review, we provide a concise overview of major membrane trafficking pathways and detail adaptations in these pathways, including COPII-dependent endoplasmic reticulum (ER)-to-Golgi vesicle trafficking, COPI-dependent retrograde Golgi-to-ER trafficking and endocytosis, that have been found in cancer. We explore how these adaptations confer growth advantages or resistance to cell death and conclude by discussing the potential for utilising this knowledge in developing new treatment strategies and overcoming drug resistance for cancer patients.
膜转运是一种基本的细胞过程，包括分子向特定细胞器的运输、质膜的内吞作用和蛋白质分泌，对于细胞的内稳态和信号转导至关重要。癌细胞适应膜转运以增强其生存和代谢能力，了解这些适应性对于提高患者对治疗的反应和确定治疗靶点至关重要。在这篇综述中，我们简要概述了主要的膜转运途径，并详细描述了这些途径中的适应性，包括 COPII 依赖性内质网（ER）-高尔基体囊泡转运、COPI 依赖性逆行高尔基体-ER 转运和内吞作用，这些适应性在癌症中已经被发现。我们探讨了这些适应性如何赋予生长优势或对细胞死亡的抗性，并通过讨论利用这些知识开发新的治疗策略和克服癌症患者的耐药性的潜力来结束讨论。
