Department of Neurosurgery, University of South Florida, Tampa, Florida, USA.
Department of Neuro-Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Neuro Oncol. 2024 Sep 5;26(9):1545-1556. doi: 10.1093/neuonc/noae087.
Drug delivery to the central nervous system (CNS) has been a major challenge for CNS tumors due to the impermeability of the blood-brain barrier (BBB). There has been a multitude of techniques aimed at overcoming the BBB obstacle aimed at utilizing natural transport mechanisms or bypassing the BBB which we review here. Another approach that has generated recent interest in the recently published literature is to use new technologies (Laser Interstitial Thermal Therapy, LITT; or Low-Intensity Focused Ultrasound, LIFU) to temporarily increase BBB permeability. This review overviews the advantages, disadvantages, and major advances of each method. LIFU has been a major area of research to allow for chemotherapeutics to cross the BBB which has a particular emphasis in this review. While most of the advances remain in animal studies, there are an increasing number of translational clinical trials that will have results in the next few years.
药物递送至中枢神经系统（CNS）一直是 CNS 肿瘤的一大挑战，这是由于血脑屏障（BBB）的不可渗透性所致。已经有许多旨在克服 BBB 障碍的技术，旨在利用天然转运机制或绕过 BBB，我们在此进行了综述。另一种方法最近在已发表的文献中引起了关注，即使用新技术（激光间质热疗（LITT）或低强度聚焦超声（LIFU））来暂时增加 BBB 的通透性。这篇综述概述了每种方法的优缺点和主要进展。LIFU 一直是允许化疗药物穿过 BBB 的主要研究领域，这在本综述中特别强调。虽然大多数进展仍处于动物研究阶段，但越来越多的转化临床试验将在未来几年内产生结果。
