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在医院疾病爆发期间,血友病男孩中结核病发病率异常高。

Unusually high incidence of tuberculosis among boys with haemophilia during an outbreak of the disease in hospital.

作者信息

Beddall A C, Hill F G, George R H, Williams M D, Al-Rubei K

出版信息

J Clin Pathol. 1985 Oct;38(10):1163-5. doi: 10.1136/jcp.38.10.1163.

Abstract

Of 30 children with bleeding disorders exposed to an index tuberculosis case, six developed primary pulmonary tuberculosis and two others became positive skin reactors. There was a significant correlation between the amount of replacement treatment received and the development of evidence of tuberculous infection. Only two of those who developed evidence of tuberculosis had antibodies to the human T cell lymphotropic virus. These two boys showed much later Mantoux positive conversion than the six others.

摘要

在30名患有出血性疾病且接触过首例结核病病例的儿童中,6人患上原发性肺结核,另外2人皮肤反应呈阳性。接受替代治疗的量与结核感染证据的出现之间存在显著相关性。在出现结核病证据的人中,只有两人有人T细胞嗜淋巴细胞病毒抗体。这两名男孩的结核菌素试验阳性转变比其他六人晚得多。

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本文引用的文献

4
Impaired cell-mediated immunity in patients with classic hemophilia.
N Engl J Med. 1983 Jan 13;308(2):79-83. doi: 10.1056/NEJM198301133080205.
6
Haemophilia and tuberculosis.血友病与结核病。
Lancet. 1983 May 28;1(8335):1226. doi: 10.1016/s0140-6736(83)92510-2.
9
A tuberculosis outbreak in Deal, Kent.肯特郡迪尔发生的一起结核病疫情。
Lancet. 1982 May 8;1(8280):1060-1. doi: 10.1016/s0140-6736(82)92110-9.

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