Bolton-Maggs P, Wilkinson L S
Clin Lab Haematol. 1984;6(3):247-56.
Of 120 patients presenting with mild bleeding disorders, 63 were found to have a definite coagulopathy. The commonest disorders were haemophilia, Christmas disease and von Willebrand's disease (vWd), the latter being predominant. Diagnosis led to prophylactic treatment prior to surgery in 18 patients with prevention of excessive haemorrhage. Three patients who had received blood products developed hepatitis. DDAVP (desamino-cys-1-8-D-arginine vasopressin) is the treatment of choice in suitable mildly affected patients with haemophilia A and vWd. Examination of blood group distribution suggests an excess of group O among patients with bleeding disorders, especially those with vWd.
在120例表现为轻度出血性疾病的患者中，有63例被发现存在明确的凝血病。最常见的疾病是血友病、克里斯马斯病和血管性血友病（vWd），其中血管性血友病最为常见。诊断后，18例患者在手术前接受了预防性治疗，防止了过度出血。3例接受血液制品治疗的患者患上了肝炎。去氨加压素（1-去氨基-8-D-精氨酸加压素）是治疗轻度血友病A和血管性血友病合适患者的首选药物。血型分布检查表明，出血性疾病患者中O型血的比例过高，尤其是血管性血友病患者。
