Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Department of Medicine, Brigham and Women's Hospital, Renal Division, Harvard Medical School, Boston, Massachusetts, USA.
J Ren Care. 2024 Jun;50(2):79-91. doi: 10.1111/jorc.12495.
Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure, or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.
从历史上看,将新的治疗方法从临床证据转化为日常实践平均需要 17 年。鉴于现在有非常有效的治疗方法可用于预防或延缓肾脏疾病的发生和进展,这个时间太长了。现在是缩小我们所知道的和我们所做的之间差距的时候了。预防和管理常见的肾脏疾病风险因素(如高血压和糖尿病)已有明确的指南,但全世界只有一小部分患有这些疾病的人得到诊断,接受目标治疗的人就更少了。同样,绝大多数患有肾脏疾病的人不知道自己的病情,因为在早期,这种疾病通常没有明显症状。即使在已经被诊断出患有肾脏疾病的患者中,也有许多人没有得到适当的肾脏疾病治疗。考虑到肾脏疾病进展、肾衰竭或死亡的严重后果,必须尽早且适当地开始治疗。必须从初级保健层面最大限度地利用早期诊断和治疗肾脏疾病的机会。从患者到临床医生再到医疗体系和社会因素,存在许多系统性障碍。为了维护和改善世界各地每个人的肾脏健康,必须承认这些障碍,以便尽快制定和实施可持续的解决方案。