Laboratory for Protein Biochemistry and Glycobiology, Biochemistry Department, University of Hyderabad, Hyderabad, India.
Developmental Biology Group, MACS-Agharkar Research Institute, Pune, India.
Int J Dev Biol. 2024 May 21;68(2):55-64. doi: 10.1387/ijdb.240009sg.
Understanding the evolution of body plans has been one of the major areas of investigation in developmental and evolutionary biology. Cnidaria, the sister group to bilaterians, provides an opportunity to elucidate the origin and evolution of body axes. , a freshwater cnidarian, is a useful model to study signaling pathways governing pattern formation, which are conserved up to vertebrates including humans. The transforming growth factor β (TGF-β) signaling pathway is one of the fundamental pathways that regulate axis formation and organogenesis during embryonic development. In this article, we discuss the TGF-β pathway members identified in along with other cnidarians with an emphasis on bone morphogenetic proteins (BMPs) and their inhibitors. TGF-β members, especially those involved in BMP signaling pathway, are mainly involved in maintaining the Organizer region and patterning the body axis in . Identification of other members of this pathway in and fellow cnidarians would provide insights into the evolution of body axes and pattern formation in more complex metazoans.
理解身体模式的进化一直是发育和进化生物学的主要研究领域之一。刺胞动物作为两侧对称动物的姊妹群，为研究身体轴的起源和进化提供了机会。淡水刺胞动物 是研究信号通路调控模式形成的有用模型，这些信号通路在包括人类在内的脊椎动物中是保守的。转化生长因子 β（TGF-β）信号通路是调节胚胎发育过程中轴形成和器官发生的基本通路之一。在本文中，我们讨论了在 中鉴定的 TGF-β途径成员，以及其他刺胞动物，重点是骨形态发生蛋白（BMPs）及其抑制剂。TGF-β成员，特别是那些参与 BMP 信号通路的成员，主要参与维持组织者区域并在 中对身体轴进行模式化。在 和其他刺胞动物中鉴定该途径的其他成员将深入了解更复杂后生动物的身体轴和模式形成的进化。
