颅底外科恶性肿瘤：第 2 次国际合作研究（1995-2015 年）。
Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015).
机构信息
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
出版信息
Head Neck. 2024 Nov;46(11):2762-2775. doi: 10.1002/hed.27746. Epub 2024 May 21.
BACKGROUND
The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.
PATIENTS AND METHODS
A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.
RESULTS
The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.
CONCLUSION
The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
背景
本研究呈现了一个全球性合作小组的努力，旨在回顾全球范围内颅底恶性肿瘤的治疗和结果。
患者和方法
共有 28 家机构提供了 3061 名患者的数据。分析评估了临床变量、生存结果以及与结果相关的多变量因素。
结果
中位年龄为 56 岁（IQR 44-67）。55%（n=1680）的病例采用开放式手术方法，36%（n=1087）采用内镜切除，9.6%（n=294）采用联合方法。中位随访时间为 7.1 年，5 年 OS DSS 和 RFS 分别为 65%、71.7%和 53%。多变量分析显示，年龄较大、合并症、组织学、硬脑膜/颅内受累、阳性切缘、晚期和原发部位是 OS、DSS 和 RFS 的独立预后因素。辅助放疗是一种保护预后因素。
结论
与以往的报告相比，本研究中跨不同学科的进展可能有助于提高 OS 和 DSS。
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