Fayez M, Ahmed H H, Quadri S K
Life Sci. 1985 Nov 18;37(20):1877-80. doi: 10.1016/0024-3205(85)90004-9.
A single iv injection of 15 or 30 but not 7.5 mg/kg BW of an antiviral drug, amantadine, significantly (P less than 0.05) decreased plasma prolactin (PRL) concentrations in male rats. This effect was dose-dependent, with the highest dose producing a longer-lasting decrease in plasma PRL. The amantadine-induced decrease was unaffected by a simultaneous injection of 5-hydroxytryptophan (30 mg/kg BW) but was completely blocked by a simultaneous injection of haloperidol (0.05 mg/kg BW). It is concluded that this novel effect of amantadine on PRL is produced by an interaction with the dopaminergic system.
单次静脉注射15或30mg/kg体重（而非7.5mg/kg体重）的抗病毒药物金刚烷胺，可显著（P<0.05）降低雄性大鼠血浆催乳素（PRL）浓度。这种效应呈剂量依赖性，最高剂量导致血浆PRL浓度下降的持续时间更长。金刚烷胺引起的下降不受同时注射5-羟色氨酸（30mg/kg体重）的影响，但被同时注射氟哌啶醇（0.05mg/kg体重）完全阻断。结论是，金刚烷胺对PRL的这种新效应是通过与多巴胺能系统相互作用产生的。
