Preziosi P, Cerrito F, Vacca M
Brain Res. 1983 Jul 25;271(2):379-85. doi: 10.1016/0006-8993(83)90306-2.
A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the intracerebroventricular route, etomidate strongly reduced serum prolactin levels in unanesthetized rats. Studies performed on superfused synaptosomes from brain areas rich in dopaminergic nerve endings did not show any influence of the etomidate, 10(-7) M-10(-6) M, on [3H]dopamine release. A peculiar GABA-like mechanism and/or possible interplay with serotonergic control of the prolactin release may be postulated in order to explain the suppressive effects of the drug on secretion of lactotrophs.
一种短效非巴比妥类静脉全身麻醉药依托咪酯，静脉注射时可降低大鼠血清催乳素水平。在静息状态、手术应激后或注射5-羟色氨酸后，该作用明显。氟哌啶醇诱导的高催乳素血症未被改变。通过脑室内途径给药，依托咪酯可显著降低未麻醉大鼠的血清催乳素水平。对富含多巴胺能神经末梢的脑区的离体突触体进行的研究未显示10(-7)M - 10(-6)M的依托咪酯对[3H]多巴胺释放有任何影响。为了解释该药物对促乳素细胞分泌的抑制作用，可能推测存在一种特殊的γ-氨基丁酸样机制和/或与催乳素释放的5-羟色胺能控制的可能相互作用。
